DOI: 10.1073/pnas.0230529100. Pitx3 is required for development of substantia nigra dopaminergic neurons

Pitx3 is required for development of substantia nigra dopaminergic neurons

10.1073/pnas.0230529100

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Dopaminergic (DA) neurons of substantia nigra in the midbrain control voluntary movement, and their degeneration is the cause of Parkinson's disease. The complete set of genes required to specifically determine the development of midbrain DA subgroups is not known yet. We report here that mice lacking the bicoid -related homeoprotein Pitx3 fail to develop DA neurons of the substantia nigra. Other mesencephalic DA neurons of the ventral tegmental area and retrorubral field are unaltered in their dopamine expression and histological organization. These data suggest that Pitx3-dependent gene expression is specifically required for the differentiation of DA progenitors within the mesencephalic DA system.

Bibliography

Nunes, I., Tovmasian, L. T., Silva, R. M., Burke, R. E., & Goff, S. P. (2003). Pitx3 is required for development of substantia nigra dopaminergic neurons. Proceedings of the National Academy of Sciences, 100(7), 4245â4250.

Authors 5

Irene Nunes (first)
Lucy T. Tovmasian (additional)
Robert M. Silva (additional)
Robert E. Burke (additional)
Stephen P. Goff (additional)

References 24 Referenced 322

10.1038/365441a0
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A Bjorklund, O Lindvall Classical Transmitters in the CNS: Part I, eds A Bjorklund, T Hokfelt (Elsevier Science, Amsterdam), pp. 55–122 (1984). / Classical Transmitters in the CNS: Part I by Bjorklund A (1984)
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Dates

Type	When
Created	22 years, 4 months ago (April 1, 2003, 2:25 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 10:05 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 3, 2025, 12:16 a.m.)
Issued	22 years, 5 months ago (March 24, 2003)
Published	22 years, 5 months ago (March 24, 2003)
Published Online	22 years, 5 months ago (March 24, 2003)
Published Print	22 years, 5 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{Nunes_2003, title={Pitx3 is required for development of substantia nigra dopaminergic neurons}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0230529100}, DOI={10.1073/pnas.0230529100}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Nunes, Irene and Tovmasian, Lucy T. and Silva, Robert M. and Burke, Robert E. and Goff, Stephen P.}, year={2003}, month=mar, pages={4245–4250} }

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