DOI: 10.1073/pnas.022523499. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in <i>Caenorhabditis elegans</i> embryos

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

10.1073/pnas.022523499

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates.Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.

Bibliography

Goutte, C., Tsunozaki, M., Hale, V. A., & Priess, J. R. (2002). APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proceedings of the National Academy of Sciences, 99(2), 775â779.

Authors 4

Caroline Goutte (first)
Makoto Tsunozaki (additional)
Valerie A. Hale (additional)
James R. Priess (additional)

References 33 Referenced 324

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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:36 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 9:03 a.m.)
Indexed	2 months, 4 weeks ago (May 23, 2025, 8:26 p.m.)
Issued	23 years, 7 months ago (Jan. 15, 2002)
Published	23 years, 7 months ago (Jan. 15, 2002)
Published Online	23 years, 7 months ago (Jan. 15, 2002)
Published Print	23 years, 7 months ago (Jan. 22, 2002)

Funders 0

None

BibTeX

@article{Goutte_2002, title={APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.022523499}, DOI={10.1073/pnas.022523499}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Goutte, Caroline and Tsunozaki, Makoto and Hale, Valerie A. and Priess, James R.}, year={2002}, month=jan, pages={775–779} }

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