DOI: 10.1071/ch9630411. The Formation of 3-Phenyl-2-thiohydantoins from Phenylthiocarbamyl Amino Acids

The Formation of 3-Phenyl-2-thiohydantoins from Phenylthiocarbamyl Amino Acids

10.1071/ch9630411

Crossref journal-article

CSIRO Publishing

Australian Journal of Chemistry (67)

Abstract

In an attempt to extend the application of the phenylisothiocyanate degradation of peptides it was found necessary to study the kinetics of the conversion of phenylthiocarbamyl amino acids into phenylthiohydantoins. The conversion was found to obey first-order kinetics and to be catalyzed by hydrogen ions. A set of conditions with regard to time, hydrogen ion concentration and temperature was found, which allowed the quantitative or near quantitative conversion of all phenylthiocarbamyl amino acids into phenylthiohydantoins with the only exception of the phenylthiohydantoin of serine, which was returned in a yield of 20%.

Bibliography

Ilse, D., & Edman, P. (1963). The Formation of 3-Phenyl-2-thiohydantoins from Phenylthiocarbamyl Amino Acids. Australian Journal of Chemistry, 16(3), 411.

Authors 2

D Ilse (first)
P Edman (additional)

References 0 Referenced 97

None

Dates

Type	When
Created	15 years ago (Sept. 1, 2010, 11:31 p.m.)
Deposited	6 years, 9 months ago (Nov. 21, 2018, 12:36 a.m.)
Indexed	10 hours, 45 minutes ago (Sept. 4, 2025, 9:24 a.m.)
Issued	62 years, 8 months ago (Jan. 1, 1963)
Published	62 years, 8 months ago (Jan. 1, 1963)
Published Print	62 years, 8 months ago (Jan. 1, 1963)

Funders 0

None

BibTeX

@article{Ilse_1963, title={The Formation of 3-Phenyl-2-thiohydantoins from Phenylthiocarbamyl Amino Acids}, volume={16}, ISSN={0004-9425}, url={http://dx.doi.org/10.1071/ch9630411}, DOI={10.1071/ch9630411}, number={3}, journal={Australian Journal of Chemistry}, publisher={CSIRO Publishing}, author={Ilse, D and Edman, P}, year={1963}, pages={411} }

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