DOI: 10.1063/1.466975. Predictions of free energy differences from a single simulation of the initial state

Predictions of free energy differences from a single simulation of the initial state

10.1063/1.466975

Crossref journal-article

AIP Publishing

The Journal of Chemical Physics (317)

Abstract

We have investigated the feasibility of using higher derivatives of the free energy, with respect to a coupling parameter λ, for predicting free energy changes between different states from a single simulation corresponding to the initial state, i.e., λ=0 in the normal thermodynamic integration approach. Terms up to and including the fifth derivative have been used. For a diatomic with point charges (dipole moment=2.4 D) in a box of water, the free energy corresponding to charge rearrangements of the order of ±0.25e could be predicted accurately after 750 ps of simulation and inclusion of the third derivative. Predictions were best for small perturbations. After 1000 ps of simulation, the first, second, third, and probably the fourth derivatives had converged, while the fifth was still oscillating. The possibility of predicting a multitude of free energy changes from a single simulation is discussed.

Bibliography

Smith, P. E., & Gunsteren, W. F. van. (1994). Predictions of free energy differences from a single simulation of the initial state. The Journal of Chemical Physics, 100(1), 577â585.

Authors 2

Paul E. Smith (first)
Wilfred F. van Gunsteren (additional)

References 18 Referenced 57

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{'key': '2024020710220030700_r2'}
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{'key': '2024020710220030700_r16'}
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 8:12 a.m.)
Deposited	1 year, 6 months ago (Feb. 7, 2024, 11:11 a.m.)
Indexed	2 months, 3 weeks ago (June 5, 2025, 7:47 a.m.)
Issued	31 years, 7 months ago (Jan. 1, 1994)
Published	31 years, 7 months ago (Jan. 1, 1994)
Published Print	31 years, 7 months ago (Jan. 1, 1994)

Funders 0

None

BibTeX

@article{Smith_1994, title={Predictions of free energy differences from a single simulation of the initial state}, volume={100}, ISSN={1089-7690}, url={http://dx.doi.org/10.1063/1.466975}, DOI={10.1063/1.466975}, number={1}, journal={The Journal of Chemical Physics}, publisher={AIP Publishing}, author={Smith, Paul E. and Gunsteren, Wilfred F. van}, year={1994}, month=jan, pages={577–585} }

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