DOI: 10.1063/1.325219. Magnetic guidance of drug-carrying microspheres

Magnetic guidance of drug-carrying microspheres

10.1063/1.325219

Crossref journal-article

AIP Publishing

Journal of Applied Physics (317)

Abstract

Physical laws underlying the intravascular magnetic guidance of a novel drug carrier are discussed. The drug carrier is a magnetically responsive drug-bearing microsphere measuring approximately 1 μm in diameter. The microspheres consist of an albumin matrix in which a prototype drug (adriamycin HCl) and ultrafine Fe3O4 particles are entrapped. An in vitro analog of the human circulatory system is used to test both bipolar and unipolar magnetic arrangements which can retain microspheres flowing in aqueous suspension in the area of applied magnetic field. Retention of the microspheres by the magnetic field is shown to vary with the linear velocity of the viscous suspending medium and to be dependent on the magnitude of the applied magnetic force. This system permits extracorporeal control over the distribution of intravascular soluble chemotherapeutic agents and allows their concentration at specified body sites.

Bibliography

Senyei, A., Widder, K., & Czerlinski, G. (1978). Magnetic guidance of drug-carrying microspheres. Journal of Applied Physics, 49(6), 3578â3583.

Authors 3

Andrew Senyei (first)
Kenneth Widder (additional)
George Czerlinski (additional)

References 16 Referenced 276

{'key': '2024020420493205800_r1'}
10.3109/00016925109136646 / Acta Radiol. (1951)
{'key': '2024020420493205800_r3', 'first-page': '45', 'volume': '38', 'year': '1973', 'journal-title': 'J. Neurosurg.'} / J. Neurosurg. (1973)
10.1056/NEJM197508282930905 / N. Engl. J. Med. (1975)
{'key': '2024020420493205800_r5', 'first-page': '1068', 'volume': '90', 'year': '1963', 'journal-title': 'Am. J. Roentgenol.'} / Am. J. Roentgenol. (1963)
10.1148/113.3.529 / Radiology (1974)
{'key': '2024020420493205800_r7', 'first-page': '11', 'volume': '5', 'year': '1966', 'journal-title': 'Med. Res. Eng.'} / Med. Res. Eng. (1966)
10.1063/1.1660237 / J. Appl. Phys. (1971)
{'key': '2024020420493205800_r9', 'first-page': '105', 'volume': '5', 'year': '1965', 'journal-title': 'Am. Inst. Chem. Symp. Ser.'} / Am. Inst. Chem. Symp. Ser. (1965)
{'key': '2024020420493205800_r10', 'first-page': '212', 'volume': '60', 'year': '1966', 'journal-title': 'Surgery'} / Surgery (1966)
10.1097/00000658-197311000-00021 / Ann. Surg. (1973)
{'key': '2024020420493205800_r12'}
{'key': '2024020420493205800_r13'}
10.1063/1.1657523 / Appl. Phys. (1969)
{'key': '2024020420493205800_r15'}
10.1063/1.1658812 / J. Appl. Phys. (1970)

Dates

Type	When
Created	22 years, 6 months ago (Feb. 14, 2003, 4:46 p.m.)
Deposited	1 year, 6 months ago (Feb. 4, 2024, 3:49 p.m.)
Indexed	4 days, 3 hours ago (Aug. 26, 2025, 3:10 a.m.)
Issued	47 years, 2 months ago (June 1, 1978)
Published	47 years, 2 months ago (June 1, 1978)
Published Print	47 years, 2 months ago (June 1, 1978)

Funders 0

None

BibTeX

@article{Senyei_1978, title={Magnetic guidance of drug-carrying microspheres}, volume={49}, ISSN={1089-7550}, url={http://dx.doi.org/10.1063/1.325219}, DOI={10.1063/1.325219}, number={6}, journal={Journal of Applied Physics}, publisher={AIP Publishing}, author={Senyei, Andrew and Widder, Kenneth and Czerlinski, George}, year={1978}, month=jun, pages={3578–3583} }

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