DOI: 10.1063/1.2757171. Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system

Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system

10.1063/1.2757171

Crossref journal-article

AIP Publishing

The Journal of Chemical Physics (317)

Abstract

We study the dynamics of hydration water in the protein lysozyme in the temperature range 180K&lt;T&lt;360K using Fourier-transform-infrared and nuclear magnetic resonance (NMR) spectroscopies. By analyzing the thermal evolution of spectra of the OH-stretching vibration modes and the NMR self-diffusion (DS) and spin-lattice relaxation time (T1), we demonstrate the existence of two dynamical transitions in the protein hydration water. Below the first transition, at about 220K, the hydration water displays an unambiguous fragile-to-strong dynamic crossover, resulting in the loss of the protein conformational flexibility. Above the second transition, at about 346K, where the protein unfolds, the dynamics of the hydration water appears to be dominated by the non-hydrogen-bonded fraction of water molecules.

Bibliography

Mallamace, F., Chen, S.-H., Broccio, M., Corsaro, C., Crupi, V., Majolino, D., Venuti, V., Baglioni, P., Fratini, E., Vannucci, C., & Stanley, H. E. (2007). Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system. The Journal of Chemical Physics, 127(4).

Authors 11

Francesco Mallamace (first)
Sow-Hsin Chen (additional)
Matteo Broccio (additional)
Carmelo Corsaro (additional)
Vincenza Crupi (additional)
Domenico Majolino (additional)
Valentina Venuti (additional)
Piero Baglioni (additional)
Emiliano Fratini (additional)
Chiara Vannucci (additional)
H. Eugene Stanley (additional)

References 37 Referenced 92

{'volume-title': 'Protein Solvent Interaction', 'year': '1995', 'key': '2023080208170367700_c1'} / Protein Solvent Interaction (1995)
{'key': '2023080208170367700_c2', 'first-page': '1', 'volume-title': 'Water: a Comprehensive Treatise', 'author': 'Franks', 'year': '1982'} / Water: a Comprehensive Treatise by Franks (1982)
{'key': '2023080208170367700_c3a', 'first-page': '40', 'volume': '56', 'year': '2003', 'journal-title': 'Phys. Today'} / Phys. Today (2003)
10.1088/0953-8984/15/45/R01 / J. Phys.: Condens. Matter (2003)
10.1038/24540 / Nature (London) (1998)
10.1146/annurev.bb.20.060191.003045 / Annu. Rev. Biophys. Biophys. Chem. (1991)
10.1021/bk-1980-0127 / Water in Polymers by Rowland (1980)
10.1103/PhysRevLett.62.1916 / Phys. Rev. Lett. (1989)
10.1126/science.267.5206.1924 / Science (1995)
10.1073/pnas.81.22.7088 / Proc. Natl. Acad. Sci. U.S.A. (1984)
10.1038/337754a0 / Nature (London) (1989)
10.1038/357423a0 / Nature (London) (1992)
{'key': '2023080208170367700_c12', 'first-page': '868', 'volume': '307–310', 'year': '2002', 'journal-title': 'J. Non-Cryst. Solids'} / J. Non-Cryst. Solids (2002)
10.1021/jp025587d / J. Phys. Chem. B (2002)
10.1038/360324a0 / Nature (London) (1992)
{'key': '2023080208170367700_c15', 'first-page': '411', 'volume': '455', 'year': '1997', 'journal-title': 'Mater. Res. Soc. Symp. Proc.'} / Mater. Res. Soc. Symp. Proc. (1997)
10.1103/PhysRevLett.73.1632 / Phys. Rev. Lett. (1994)
10.1021/j100011a054 / J. Phys. Chem. (1995)
10.1103/PhysRevLett.95.117802 / Phys. Rev. Lett. (2005)
10.1063/1.2193159 / J. Chem. Phys. (2006)
10.1073/pnas.0507870102 / Proc. Natl. Acad. Sci. U.S.A. (2005)
10.1038/19042 / Nature (London) (1999)
10.1146/annurev.physchem.51.1.99 / Annu. Rev. Phys. Chem. (2000)
10.1073/pnas.0603253103 / Proc. Natl. Acad. Sci. U.S.A. (2006)
10.1073/pnas.0607138104 / Proc. Natl. Acad. Sci. U.S.A. (2007)
{'key': '2023080208170367700_c25', 'first-page': '9016', 'volume': '103', 'year': '2006', 'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'} / Proc. Natl. Acad. Sci. U.S.A. (2006)
10.1103/PhysRevLett.97.177802 / Phys. Rev. Lett. (2006)
10.1103/PhysRevLett.89.275501 / Phys. Rev. Lett. (2002)
10.1103/PhysRevLett.95.038101 / Phys. Rev. Lett. (2005)
{'key': '2023080208170367700_c29', 'first-page': '151', 'volume-title': 'in Water: A Comprehensive Treatise', 'author': 'Franks', 'year': '1972'} / in Water: A Comprehensive Treatise by Franks (1972)
10.1209/epl/i2004-10529-2 / Europhys. Lett. (2005)
10.1063/1.1894929 / J. Chem. Phys. (2005)
10.1063/1.451383 / J. Chem. Phys. (1986)
10.1038/35053024 / Nature (London) (2001)
10.1103/PhysRev.73.679 / Phys. Rev. (1948)
10.1063/1.1695690 / J. Chem. Phys. (1964)
10.1063/1.442629 / J. Chem. Phys. (1995)

Dates

Type	When
Created	18 years ago (July 31, 2007, 7:57 p.m.)
Deposited	2 years ago (Aug. 2, 2023, 4:18 a.m.)
Indexed	3 weeks, 4 days ago (July 30, 2025, 6:49 a.m.)
Issued	18 years ago (July 28, 2007)
Published	18 years ago (July 28, 2007)
Published Online	18 years ago (July 31, 2007)
Published Print	18 years ago (July 28, 2007)

Funders 0

None

BibTeX

@article{Mallamace_2007, title={Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system}, volume={127}, ISSN={1089-7690}, url={http://dx.doi.org/10.1063/1.2757171}, DOI={10.1063/1.2757171}, number={4}, journal={The Journal of Chemical Physics}, publisher={AIP Publishing}, author={Mallamace, Francesco and Chen, Sow-Hsin and Broccio, Matteo and Corsaro, Carmelo and Crupi, Vincenza and Majolino, Domenico and Venuti, Valentina and Baglioni, Piero and Fratini, Emiliano and Vannucci, Chiara and Stanley, H. Eugene}, year={2007}, month=jul }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T10:49:50Z",
    "timestamp": 1753872590405,
    "version": "3.41.2"
  },
  "reference-count": 37,
  "publisher": "AIP Publishing",
  "issue": "4",
  "content-domain": {
    "domain": [
      "pubs.aip.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        7,
        28
      ]
    ]
  },
  "abstract": "<jats:p>We study the dynamics of hydration water in the protein lysozyme in the temperature range 180K&amp;lt;T&amp;lt;360K using Fourier-transform-infrared and nuclear magnetic resonance (NMR) spectroscopies. By analyzing the thermal evolution of spectra of the OH-stretching vibration modes and the NMR self-diffusion (DS) and spin-lattice relaxation time (T1), we demonstrate the existence of two dynamical transitions in the protein hydration water. Below the first transition, at about 220K, the hydration water displays an unambiguous fragile-to-strong dynamic crossover, resulting in the loss of the protein conformational flexibility. Above the second transition, at about 346K, where the protein unfolds, the dynamics of the hydration water appears to be dominated by the non-hydrogen-bonded fraction of water molecules.</jats:p>",
  "DOI": "10.1063/1.2757171",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        7,
        31
      ]
    ],
    "date-time": "2007-07-31T23:57:03Z",
    "timestamp": 1185926223000
  },
  "update-policy": "https://doi.org/10.1063/aip-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 92,
  "title": "Role of the solvent in the dynamical transitions of proteins: The case of the lysozyme-water system",
  "prefix": "10.1063",
  "volume": "127",
  "author": [
    {
      "given": "Francesco",
      "family": "Mallamace",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; and Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; and Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA"
        },
        {
          "name": "Massachusetts Institute of Technology Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy; and Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA"
        }
      ]
    },
    {
      "given": "Sow-Hsin",
      "family": "Chen",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Massachusetts Institute of Technology Department of Nuclear Science and Engineering, , Cambridge, Massachusetts 02139, USA"
        }
      ]
    },
    {
      "given": "Matteo",
      "family": "Broccio",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        }
      ]
    },
    {
      "given": "Carmelo",
      "family": "Corsaro",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        }
      ]
    },
    {
      "given": "Vincenza",
      "family": "Crupi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        }
      ]
    },
    {
      "given": "Domenico",
      "family": "Majolino",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        }
      ]
    },
    {
      "given": "Valentina",
      "family": "Venuti",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        },
        {
          "name": "Universit\u00e0 di Messina Dipartimento di Fisica, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy and CNISM, , C. da Papardo, S. ta Sperone 31, 98166 Messina, Italy"
        }
      ]
    },
    {
      "given": "Piero",
      "family": "Baglioni",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        },
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        }
      ]
    },
    {
      "given": "Emiliano",
      "family": "Fratini",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        },
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        }
      ]
    },
    {
      "given": "Chiara",
      "family": "Vannucci",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        },
        {
          "name": "Universit\u00e0 di Firenze Department of Chemistry, , Via Lastruccia 3, 50019 Firenze, Italy and CSGI, , Via Lastruccia 3, 50019 Firenze, Italy"
        }
      ]
    },
    {
      "given": "H. Eugene",
      "family": "Stanley",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Boston University Centre for Polymer Studies, , Boston, Massachusetts 02215, USA and Department of Physics, , Boston, Massachusetts 02215, USA"
        },
        {
          "name": "Boston University Centre for Polymer Studies, , Boston, Massachusetts 02215, USA and Department of Physics, , Boston, Massachusetts 02215, USA"
        }
      ]
    }
  ],
  "member": "317",
  "published-online": {
    "date-parts": [
      [
        2007,
        7,
        31
      ]
    ]
  },
  "reference": [
    {
      "volume-title": "Protein Solvent Interaction",
      "year": "1995",
      "key": "2023080208170367700_c1"
    },
    {
      "key": "2023080208170367700_c2",
      "first-page": "1",
      "volume-title": "Water: a Comprehensive Treatise",
      "author": "Franks",
      "year": "1982"
    },
    {
      "key": "2023080208170367700_c3a",
      "first-page": "40",
      "volume": "56",
      "year": "2003",
      "journal-title": "Phys. Today"
    },
    {
      "key": "2023080208170367700_c3b",
      "doi-asserted-by": "publisher",
      "first-page": "R1669",
      "DOI": "10.1088/0953-8984/15/45/R01",
      "volume": "15",
      "year": "2003",
      "journal-title": "J. Phys.: Condens. Matter"
    },
    {
      "key": "2023080208170367700_c4",
      "doi-asserted-by": "publisher",
      "first-page": "329",
      "DOI": "10.1038/24540",
      "volume": "396",
      "year": "1998",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c5",
      "doi-asserted-by": "publisher",
      "first-page": "577",
      "DOI": "10.1146/annurev.bb.20.060191.003045",
      "volume": "20",
      "year": "1991",
      "journal-title": "Annu. Rev. Biophys. Biophys. Chem."
    },
    {
      "key": "2023080208170367700_c6",
      "doi-asserted-by": "crossref",
      "DOI": "10.1021/bk-1980-0127",
      "volume-title": "Water in Polymers",
      "author": "Rowland",
      "year": "1980"
    },
    {
      "key": "2023080208170367700_c7",
      "doi-asserted-by": "publisher",
      "first-page": "1916",
      "DOI": "10.1103/PhysRevLett.62.1916",
      "volume": "62",
      "year": "1989",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c8",
      "doi-asserted-by": "publisher",
      "first-page": "1924",
      "DOI": "10.1126/science.267.5206.1924",
      "volume": "267",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2023080208170367700_c9",
      "doi-asserted-by": "crossref",
      "first-page": "7088",
      "DOI": "10.1073/pnas.81.22.7088",
      "volume": "81",
      "year": "1984",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "2023080208170367700_c10",
      "doi-asserted-by": "publisher",
      "first-page": "754",
      "DOI": "10.1038/337754a0",
      "volume": "337",
      "year": "1989",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c11",
      "doi-asserted-by": "publisher",
      "first-page": "423",
      "DOI": "10.1038/357423a0",
      "volume": "357",
      "year": "1992",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c12",
      "first-page": "868",
      "volume": "307\u2013310",
      "year": "2002",
      "journal-title": "J. Non-Cryst. Solids"
    },
    {
      "key": "2023080208170367700_c13",
      "doi-asserted-by": "publisher",
      "first-page": "6081",
      "DOI": "10.1021/jp025587d",
      "volume": "106",
      "year": "2002",
      "journal-title": "J. Phys. Chem. B"
    },
    {
      "key": "2023080208170367700_c14",
      "doi-asserted-by": "publisher",
      "first-page": "324",
      "DOI": "10.1038/360324a0",
      "volume": "360",
      "year": "1992",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c15",
      "first-page": "411",
      "volume": "455",
      "year": "1997",
      "journal-title": "Mater. Res. Soc. Symp. Proc."
    },
    {
      "key": "2023080208170367700_c16",
      "doi-asserted-by": "publisher",
      "first-page": "1632",
      "DOI": "10.1103/PhysRevLett.73.1632",
      "volume": "73",
      "year": "1994",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c17",
      "doi-asserted-by": "publisher",
      "first-page": "3781",
      "DOI": "10.1021/j100011a054",
      "volume": "99",
      "year": "1995",
      "journal-title": "J. Phys. Chem."
    },
    {
      "key": "2023080208170367700_c18",
      "doi-asserted-by": "publisher",
      "first-page": "117802",
      "DOI": "10.1103/PhysRevLett.95.117802",
      "volume": "95",
      "year": "2005",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c19",
      "doi-asserted-by": "publisher",
      "first-page": "161102",
      "DOI": "10.1063/1.2193159",
      "volume": "124",
      "year": "2006",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "2023080208170367700_c20",
      "doi-asserted-by": "publisher",
      "first-page": "16558",
      "DOI": "10.1073/pnas.0507870102",
      "volume": "102",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "2023080208170367700_c21",
      "doi-asserted-by": "publisher",
      "first-page": "492",
      "DOI": "10.1038/19042",
      "volume": "398",
      "year": "1999",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c22",
      "doi-asserted-by": "publisher",
      "first-page": "99",
      "DOI": "10.1146/annurev.physchem.51.1.99",
      "volume": "51",
      "year": "2000",
      "journal-title": "Annu. Rev. Phys. Chem."
    },
    {
      "key": "2023080208170367700_c23",
      "doi-asserted-by": "crossref",
      "first-page": "12974",
      "DOI": "10.1073/pnas.0603253103",
      "volume": "103",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "2023080208170367700_c24",
      "doi-asserted-by": "crossref",
      "first-page": "424",
      "DOI": "10.1073/pnas.0607138104",
      "volume": "104",
      "year": "2007",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "2023080208170367700_c25",
      "first-page": "9016",
      "volume": "103",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "2023080208170367700_c26",
      "doi-asserted-by": "publisher",
      "first-page": "177802",
      "DOI": "10.1103/PhysRevLett.97.177802",
      "volume": "97",
      "year": "2006",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c27",
      "doi-asserted-by": "publisher",
      "first-page": "275501",
      "DOI": "10.1103/PhysRevLett.89.275501",
      "volume": "89",
      "year": "2002",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c28",
      "doi-asserted-by": "publisher",
      "first-page": "038101",
      "DOI": "10.1103/PhysRevLett.95.038101",
      "volume": "95",
      "year": "2005",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "2023080208170367700_c29",
      "first-page": "151",
      "volume-title": "in Water: A Comprehensive Treatise",
      "author": "Franks",
      "year": "1972"
    },
    {
      "key": "2023080208170367700_c30",
      "doi-asserted-by": "publisher",
      "first-page": "91",
      "DOI": "10.1209/epl/i2004-10529-2",
      "volume": "71",
      "year": "2005",
      "journal-title": "Europhys. Lett."
    },
    {
      "key": "2023080208170367700_c31",
      "doi-asserted-by": "publisher",
      "first-page": "184509",
      "DOI": "10.1063/1.1894929",
      "volume": "122",
      "year": "2005",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "2023080208170367700_c32",
      "doi-asserted-by": "publisher",
      "first-page": "6964",
      "DOI": "10.1063/1.451383",
      "volume": "85",
      "year": "1986",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "2023080208170367700_c33",
      "doi-asserted-by": "publisher",
      "first-page": "318",
      "DOI": "10.1038/35053024",
      "volume": "409",
      "year": "2001",
      "journal-title": "Nature (London)"
    },
    {
      "key": "2023080208170367700_c34",
      "doi-asserted-by": "publisher",
      "first-page": "679",
      "DOI": "10.1103/PhysRev.73.679",
      "volume": "73",
      "year": "1948",
      "journal-title": "Phys. Rev."
    },
    {
      "key": "2023080208170367700_c35",
      "doi-asserted-by": "publisher",
      "first-page": "288",
      "DOI": "10.1063/1.1695690",
      "volume": "42",
      "year": "1964",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "2023080208170367700_c36",
      "doi-asserted-by": "publisher",
      "first-page": "4264",
      "DOI": "10.1063/1.442629",
      "volume": "75",
      "year": "1995",
      "journal-title": "J. Chem. Phys."
    }
  ],
  "container-title": "The Journal of Chemical Physics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.aip.org/aip/jcp/article-pdf/doi/10.1063/1.2757171/13265025/045104_1_online.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://pubs.aip.org/aip/jcp/article-pdf/doi/10.1063/1.2757171/13265025/045104_1_online.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        8,
        2
      ]
    ],
    "date-time": "2023-08-02T08:18:41Z",
    "timestamp": 1690964321000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.aip.org/jcp/article/127/4/045104/936407/Role-of-the-solvent-in-the-dynamical-transitions"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        7,
        28
      ]
    ]
  },
  "references-count": 37,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2007,
          7,
          28
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1063/1.2757171",
  "relation": {},
  "ISSN": [
    "0021-9606",
    "1089-7690"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        2007,
        7,
        28
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        2007,
        7,
        28
      ]
    ]
  },
  "article-number": "045104"
}