DOI: 10.1063/1.1545087. Resistance proof, folding-inhibitor drugs

Resistance proof, folding-inhibitor drugs

10.1063/1.1545087

Crossref journal-article

AIP Publishing

The Journal of Chemical Physics (317)

Abstract

Conventional drugs work, as a rule, by inhibiting the enzymatic activity of specific proteins, capping their active site. In this paper we present a model of nonconventional drug design based on the inhibiting effects small peptides obtained from segments of the protein itself have on the folding ability of the system. Such peptides attach to the newly expressed (unfolded) protein and inhibit its folding, inhibition which cannot be avoided but through mutations which in any case denaturate the enzyme. These peptides, or their mimetic molecules, can be used as effective alternative drugs to those already available, displaying the advantage of not suffering from the upraise of resistance.

Bibliography

Broglia, R. A., Tiana, G., & Berera, R. (2003). Resistance proof, folding-inhibitor drugs. The Journal of Chemical Physics, 118(10), 4754â4758.

Authors 3

R. A. Broglia (first)
G. Tiana (additional)
R. Berera (additional)

References 14 Referenced 14

{'key': '2024020611343990300_r1', 'first-page': '192', 'volume': '2', 'year': '1995', 'journal-title': 'Struct. Biol.'} / Struct. Biol. (1995)
10.1021/bi962234u / Biochemistry (1997)
10.1103/PhysRevLett.72.3907 / Phys. Rev. Lett. (1994)
10.1021/ma00200a030 / Macromolecules (1989)
10.1063/1.475435 / J. Chem. Phys. (1998)
10.1021/ma00145a039 / Macromolecules (1985)
10.1063/1.1337041 / J. Chem. Phys. (2001)
10.1063/1.1361076 / J. Chem. Phys. (2001)
10.1021/bi00199a029 / Biochemistry (1994)
10.1002/prot.1158 / Proteins: Struct., Funct., Genet. (2001)
10.1002/prot.10196 / Proteins: Struct., Funct., Genet. (2002)
{'key': '2024020611343990300_r12'}
{'key': '2024020611343990300_r13', 'first-page': '2613', 'volume': '24B', 'year': '1981', 'journal-title': 'Phys. Lett.'} / Phys. Lett. (1981)
{'key': '2024020611343990300_r14'}

Dates

Type	When
Created	22 years, 6 months ago (Feb. 25, 2003, 1:42 p.m.)
Deposited	1 year, 6 months ago (Feb. 6, 2024, 7:07 a.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 9:16 a.m.)
Issued	22 years, 5 months ago (March 8, 2003)
Published	22 years, 5 months ago (March 8, 2003)
Published Print	22 years, 5 months ago (March 8, 2003)

Funders 0

None

BibTeX

@article{Broglia_2003, title={Resistance proof, folding-inhibitor drugs}, volume={118}, ISSN={1089-7690}, url={http://dx.doi.org/10.1063/1.1545087}, DOI={10.1063/1.1545087}, number={10}, journal={The Journal of Chemical Physics}, publisher={AIP Publishing}, author={Broglia, R. A. and Tiana, G. and Berera, R.}, year={2003}, month=mar, pages={4754–4758} }

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