DOI: 10.1063/1.1521159. Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics

Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics

10.1063/1.1521159

Crossref journal-article

AIP Publishing

The Journal of Chemical Physics (317)

Abstract

This article reviews our efforts in understanding dynamical fluctuations of both conformation and enzymatic reactivity in single biomolecules. The single-molecule approach is shown to be particularly powerful for studies of dispersed kinetics and dynamic disorder. New single-molecule observations have revealed conformational transitions occurring on a broad range of timescales, 100 μs–10 s, offering new clues for understanding energy landscape of proteins, as well as the structural and chemical dynamics therein.

Bibliography

Sunney Xie, X. (2002). Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics. The Journal of Chemical Physics, 117(24), 11024â11032.

Authors 1

X. Sunney Xie (first)

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Dates

Type	When
Created	22 years, 8 months ago (Dec. 12, 2002, 11:41 a.m.)
Deposited	1 year, 6 months ago (Feb. 11, 2024, 5:28 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 6, 2025, 8:22 a.m.)
Issued	22 years, 8 months ago (Dec. 22, 2002)
Published	22 years, 8 months ago (Dec. 22, 2002)
Published Print	22 years, 8 months ago (Dec. 22, 2002)

Funders 0

None

BibTeX

@article{Sunney_Xie_2002, title={Single-molecule approach to dispersed kinetics and dynamic disorder: Probing conformational fluctuation and enzymatic dynamics}, volume={117}, ISSN={1089-7690}, url={http://dx.doi.org/10.1063/1.1521159}, DOI={10.1063/1.1521159}, number={24}, journal={The Journal of Chemical Physics}, publisher={AIP Publishing}, author={Sunney Xie, X.}, year={2002}, month=dec, pages={11024–11032} }

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