DOI: 10.1056/nejm199502023320506. Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

10.1056/nejm199502023320506

Crossref journal-article

Massachusetts Medical Society

New England Journal of Medicine (150)

Bibliography

Manolagas, S. C., & Jilka, R. L. (1995). Bone Marrow, Cytokines, and Bone Remodeling â Emerging Insights into the Pathophysiology of Osteoporosis. New England Journal of Medicine, 332(5), 305â311.

Authors 2

Stavros C. Manolagas (first)
Robert L. Jilka (additional)

References 62 Referenced 1,321

10.1002/jcb.240550303
{'key': 'r002', 'first-page': '99', 'volume': '31', 'author': 'Parfitt AM', 'year': '1992', 'journal-title': 'Triangle'} / Triangle by Parfitt AM (1992)
10.3181/00379727-205-43711 / Proc Soc Exp Biol Med by Shevde N (1994)
{'key': 'r004', 'first-page': '66', 'volume': '13', 'author': 'Suda T', 'year': '1992', 'journal-title': 'Endocr Rev'} / Endocr Rev by Suda T (1992)
Owen M. Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA, ed. Bone and mineral research/3. Amsterdam: Elsevier, 1985:1-25.
10.1002/jcp.1041580322
{'key': 'r007', 'first-page': '294', 'volume': '151', 'author': 'Ashton BA', 'year': '1980', 'journal-title': 'Clin Orthop Rel Res'} / Clin Orthop Rel Res by Ashton BA (1980)
10.1002/jcp.1041400102
10.1007/BF02556119
Mundy GR. Local factors regulating osteoclast function. In: Rifkin BR, Gay CV, eds. Biology and physiology of the osteoclast. Boca Raton, Fla.: CRC Press, 1992:171-85.
Horowitz MC, Jilka RL. Colony stimulating factors and bone remodeling. In: Gowen M, ed. Cytokines and bone metabolism. Boca Raton, Fla.: CRC Press, 1992:185-227.
10.1172/JCI117130
10.1084/jem.179.5.1677
10.1210/endo-126-5-2733
10.1210/endo-128-1-259
Marks SC Jr, Walker DG. Mammalian osteopetrosis — a model for studying cellular and humoral factors in bone resorption. In: Bourne GH, ed. The biochemistry and physiology of bone. 2nd ed. Vol. 4. New York: Academic Press, 1976:227-301. (10.1016/B978-0-12-119204-4.50013-2)
10.1007/BF01714899
10.1002/jbmr.5650071114
10.1002/jbmr.5650060307
10.4049/jimmunol.145.10.3297 / J Immunol by Ishimi Y (1990)
10.1016/0006-291X(89)90851-6
10.1210/endo-128-5-2657
10.1002/jbmr.5650060103
10.1073/pnas.90.24.11924
10.1210/en.131.5.2229
10.1182/blood.V78.5.1198.1198 / Blood by Klein B (1991)
10.1172/JCI115584
{'key': 'r029', 'first-page': 'S140', 'volume': '9', 'author': 'Kotake S', 'year': '1994', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res by Kotake S (1994)
10.1002/jbmr.5650090112
10.1002/jbmr.5650010105
10.1002/jbmr.5650020605
10.1016/0169-6009(90)90016-9
10.1210/jc.74.1.20
10.1210/jcem-67-4-741
10.1172/JCI116872
10.1002/j.1460-2075.1994.tb06368.x / EMBO J by Poli V (1994)
10.1016/0169-6009(91)90124-I
10.1210/endo-122-3-1146
Parfitt AM. Bone-forming cells in clinical conditions. In: Hall BK, ed. The osteoblast and osteocyte. Vol. 1 of Bone. Boca Raton, Fla.: Telford Press/ CRC Press, 1990:351-429.
10.1002/jbmr.5650050402
10.1172/JCI115668
10.1210/en.130.5.2528
10.1172/JCI117100
10.1016/S0021-9258(18)99966-7 / J Biol Chem by Ray A (1994)
{'key': 'r046', 'first-page': 'S131', 'volume': '8', 'author': 'Bellido T', 'year': '1993', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res by Bellido T (1993)
10.1126/science.1621100
10.1210/en.133.2.822
{'key': 'r049', 'first-page': 'S158', 'volume': '9', 'author': 'Bismar H', 'year': '1994', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res by Bismar H (1994)
10.1002/jbmr.5650090203
{'key': 'r051', 'first-page': 'S96', 'volume': '7', 'author': 'Girasole G', 'year': '1992', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res by Girasole G (1992)
10.1172/JCI117187
10.1016/S0169-6009(08)80204-8
10.1006/bbrc.1994.1217
10.1210/endo-127-4-1602
10.1073/pnas.86.15.5948
10.1016/0092-8674(94)90333-6
10.1016/0092-8674(93)90506-L
10.1016/S0169-6009(08)80206-1
{'key': 'r060', 'first-page': '276', 'volume': '125', 'author': 'Matsushita M', 'year': '1986', 'journal-title': 'Am J Pathol'} / Am J Pathol by Matsushita M (1986)
10.1002/jbmr.5650080618
{'key': 'r062', 'first-page': 'S272', 'volume': '7', 'author': 'Sato T', 'year': '1992', 'journal-title': 'J Bone Miner Res'} / J Bone Miner Res by Sato T (1992)
10.1136/bmj.289.6444.517

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 8:50 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 4:18 p.m.)
Indexed	1 day, 14 hours ago (Sept. 2, 2025, 6:35 a.m.)
Issued	30 years, 7 months ago (Feb. 2, 1995)
Published	30 years, 7 months ago (Feb. 2, 1995)
Published Print	30 years, 7 months ago (Feb. 2, 1995)

Funders 0

None

BibTeX

@article{Manolagas_1995, title={Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis}, volume={332}, ISSN={1533-4406}, url={http://dx.doi.org/10.1056/nejm199502023320506}, DOI={10.1056/nejm199502023320506}, number={5}, journal={New England Journal of Medicine}, publisher={Massachusetts Medical Society}, author={Manolagas, Stavros C. and Jilka, Robert L.}, editor={Epstein, Franklin H.}, year={1995}, month=feb, pages={305–311} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        2
      ]
    ],
    "date-time": "2025-09-02T10:35:43Z",
    "timestamp": 1756809343325
  },
  "reference-count": 62,
  "publisher": "Massachusetts Medical Society",
  "issue": "5",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1995,
        2,
        2
      ]
    ]
  },
  "DOI": "10.1056/nejm199502023320506",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        27
      ]
    ],
    "date-time": "2002-07-27T12:50:34Z",
    "timestamp": 1027774234000
  },
  "page": "305-311",
  "source": "Crossref",
  "is-referenced-by-count": 1321,
  "title": "Bone Marrow, Cytokines, and Bone Remodeling \u2014 Emerging Insights into the Pathophysiology of Osteoporosis",
  "prefix": "10.1056",
  "volume": "332",
  "author": [
    {
      "given": "Stavros C.",
      "family": "Manolagas",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Robert L.",
      "family": "Jilka",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "150",
  "reference": [
    {
      "key": "r001",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jcb.240550303"
    },
    {
      "key": "r002",
      "first-page": "99",
      "volume": "31",
      "author": "Parfitt AM",
      "year": "1992",
      "journal-title": "Triangle"
    },
    {
      "key": "r003",
      "doi-asserted-by": "crossref",
      "first-page": "306",
      "DOI": "10.3181/00379727-205-43711",
      "volume": "205",
      "author": "Shevde N",
      "year": "1994",
      "journal-title": "Proc Soc Exp Biol Med"
    },
    {
      "key": "r004",
      "first-page": "66",
      "volume": "13",
      "author": "Suda T",
      "year": "1992",
      "journal-title": "Endocr Rev"
    },
    {
      "key": "r005",
      "unstructured": "Owen M. Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA, ed. Bone and mineral research/3. Amsterdam: Elsevier, 1985:1-25."
    },
    {
      "key": "r006",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jcp.1041580322"
    },
    {
      "key": "r007",
      "first-page": "294",
      "volume": "151",
      "author": "Ashton BA",
      "year": "1980",
      "journal-title": "Clin Orthop Rel Res"
    },
    {
      "key": "r008",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jcp.1041400102"
    },
    {
      "key": "r009",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF02556119"
    },
    {
      "key": "r010",
      "unstructured": "Mundy GR. Local factors regulating osteoclast function. In: Rifkin BR, Gay CV, eds. Biology and physiology of the osteoclast. Boca Raton, Fla.: CRC Press, 1992:171-85."
    },
    {
      "key": "r011",
      "unstructured": "Horowitz MC, Jilka RL. Colony stimulating factors and bone remodeling. In: Gowen M, ed. Cytokines and bone metabolism. Boca Raton, Fla.: CRC Press, 1992:185-227."
    },
    {
      "key": "r012",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI117130"
    },
    {
      "key": "r013",
      "doi-asserted-by": "publisher",
      "DOI": "10.1084/jem.179.5.1677"
    },
    {
      "key": "r014",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-126-5-2733"
    },
    {
      "key": "r015",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-128-1-259"
    },
    {
      "key": "r016",
      "doi-asserted-by": "crossref",
      "unstructured": "Marks SC Jr, Walker DG. Mammalian osteopetrosis \u2014 a model for studying cellular and humoral factors in bone resorption. In: Bourne GH, ed. The biochemistry and physiology of bone. 2nd ed. Vol. 4. New York: Academic Press, 1976:227-301.",
      "DOI": "10.1016/B978-0-12-119204-4.50013-2"
    },
    {
      "key": "r017",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF01714899"
    },
    {
      "key": "r018",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650071114"
    },
    {
      "key": "r019",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650060307"
    },
    {
      "key": "r020",
      "doi-asserted-by": "crossref",
      "first-page": "3297",
      "DOI": "10.4049/jimmunol.145.10.3297",
      "volume": "145",
      "author": "Ishimi Y",
      "year": "1990",
      "journal-title": "J Immunol"
    },
    {
      "key": "r021",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-291X(89)90851-6"
    },
    {
      "key": "r022",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-128-5-2657"
    },
    {
      "key": "r023",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650060103"
    },
    {
      "key": "r024",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.24.11924"
    },
    {
      "key": "r026",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/en.131.5.2229"
    },
    {
      "key": "r027",
      "doi-asserted-by": "crossref",
      "first-page": "1198",
      "DOI": "10.1182/blood.V78.5.1198.1198",
      "volume": "78",
      "author": "Klein B",
      "year": "1991",
      "journal-title": "Blood"
    },
    {
      "key": "r028",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI115584"
    },
    {
      "key": "r029",
      "first-page": "S140",
      "volume": "9",
      "author": "Kotake S",
      "year": "1994",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "r030",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650090112"
    },
    {
      "key": "r031",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650010105"
    },
    {
      "key": "r032",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650020605"
    },
    {
      "key": "r033",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0169-6009(90)90016-9"
    },
    {
      "key": "r034",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/jc.74.1.20"
    },
    {
      "key": "r035",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/jcem-67-4-741"
    },
    {
      "key": "r036",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI116872"
    },
    {
      "key": "r037",
      "doi-asserted-by": "crossref",
      "first-page": "1189",
      "DOI": "10.1002/j.1460-2075.1994.tb06368.x",
      "volume": "13",
      "author": "Poli V",
      "year": "1994",
      "journal-title": "EMBO J"
    },
    {
      "key": "r038",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0169-6009(91)90124-I"
    },
    {
      "key": "r039",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-122-3-1146"
    },
    {
      "key": "r040",
      "unstructured": "Parfitt AM. Bone-forming cells in clinical conditions. In: Hall BK, ed. The osteoblast and osteocyte. Vol. 1 of Bone. Boca Raton, Fla.: Telford Press/ CRC Press, 1990:351-429."
    },
    {
      "key": "r041",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650050402"
    },
    {
      "key": "r042",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI115668"
    },
    {
      "key": "r043",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/en.130.5.2528"
    },
    {
      "key": "r044",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI117100"
    },
    {
      "key": "r045",
      "doi-asserted-by": "crossref",
      "first-page": "12940",
      "DOI": "10.1016/S0021-9258(18)99966-7",
      "volume": "269",
      "author": "Ray A",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "r046",
      "first-page": "S131",
      "volume": "8",
      "author": "Bellido T",
      "year": "1993",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "r047",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1621100"
    },
    {
      "key": "r048",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/en.133.2.822"
    },
    {
      "key": "r049",
      "first-page": "S158",
      "volume": "9",
      "author": "Bismar H",
      "year": "1994",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "r050",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650090203"
    },
    {
      "key": "r051",
      "first-page": "S96",
      "volume": "7",
      "author": "Girasole G",
      "year": "1992",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "r052",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI117187"
    },
    {
      "key": "r053",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0169-6009(08)80204-8"
    },
    {
      "key": "r054",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1994.1217"
    },
    {
      "key": "r055",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-127-4-1602"
    },
    {
      "key": "r056",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.15.5948"
    },
    {
      "key": "r057",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(94)90333-6"
    },
    {
      "key": "r058",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90506-L"
    },
    {
      "key": "r059",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0169-6009(08)80206-1"
    },
    {
      "key": "r060",
      "first-page": "276",
      "volume": "125",
      "author": "Matsushita M",
      "year": "1986",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "r061",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jbmr.5650080618"
    },
    {
      "key": "r062",
      "first-page": "S272",
      "volume": "7",
      "author": "Sato T",
      "year": "1992",
      "journal-title": "J Bone Miner Res"
    },
    {
      "key": "r063",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/bmj.289.6444.517"
    }
  ],
  "container-title": "New England Journal of Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nejm.org/doi/pdf/10.1056/NEJM199502023320506",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        23
      ]
    ],
    "date-time": "2023-04-23T20:18:16Z",
    "timestamp": 1682281096000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://www.nejm.org/doi/10.1056/NEJM199502023320506"
    }
  },
  "subtitle": [],
  "editor": [
    {
      "given": "Franklin H.",
      "family": "Epstein",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1995,
        2,
        2
      ]
    ]
  },
  "references-count": 62,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1995,
          2,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1056/NEJM199502023320506"
  ],
  "URL": "http://dx.doi.org/10.1056/NEJM199502023320506",
  "relation": {},
  "ISSN": [
    "0028-4793",
    "1533-4406"
  ],
  "subject": [],
  "container-title-short": "N Engl J Med",
  "published": {
    "date-parts": [
      [
        1995,
        2,
        2
      ]
    ]
  }
}