DOI: 10.1055/s-0038-1661109. Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

10.1055/s-0038-1661109

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryHuman plasma contains a fast-acting t-PA inhibitor, which is not identical with α2-antiplasmin or α2-macroglobulin. The concentration of this inhibitor in normal plasma is highly variable, much lower than that of known plasma protease inhibitors, and in the range of physiologically occurring plasma concentrations of t- PA (0-2 IU/ml).The inhibitor binds to concanavalin A-Sepharose, is rather stable when heated, is not precipitated in euglobulin fractions and probably does not originate from platelets. The inhibitor seems to form a 190 Kd complex with t-PA. The relation between this plasma inhibitor and the recently discovered endothelial cell inhibitor is not yet clear.

Bibliography

Verheijen, J. H., Chang, G. T. G., & Kluft, C. (1984). Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma. Thrombosis and Haemostasis, 51(03), 392â395.

Authors 3

J H Verheijen (additional)
G T G Chang (additional)
C Kluft (additional)

References 0 Referenced 251

None

Dates

Type	When
Created	7 years, 1 month ago (July 19, 2018, 6:31 p.m.)
Deposited	5 years, 8 months ago (Dec. 5, 2019, 10:19 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 9, 2024, 9:10 p.m.)
Issued	41 years, 7 months ago (Jan. 1, 1984)
Published	41 years, 7 months ago (Jan. 1, 1984)
Published Online	7 years, 1 month ago (July 19, 2018)
Published Print	41 years, 7 months ago (Jan. 1, 1984)

Funders 0

None

BibTeX

@article{Verheijen_1984, title={Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma}, volume={51}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1661109}, DOI={10.1055/s-0038-1661109}, number={03}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Verheijen, J H and Chang, G T G and Kluft, C}, year={1984}, pages={392–395} }

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