DOI: 10.1055/s-0038-1661049. Stanozolol-Induced Changes in Fibrinolysis and Coagulation in Healthy Adults

Stanozolol-Induced Changes in Fibrinolysis and Coagulation in Healthy Adults

10.1055/s-0038-1661049

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryThe effects of orally-administered stanozolol, 5 mg b. d. on fibrinolysis, coagulation and on various haematological and biochemical parameters have been studied in 16 healthy adults, 8 males and 8 females. Statistically significant enhancement of extrinsic (tissue-type) plasminogen activator activity was detected in all subjects studied. This was associated with significant increases in plasma plasminogen and a concomitant reduction in histidine-rich glycoprotein. There were no changes in plasma urokinase activity. Changes in the coagulation system included significant reduction in plasma fibrinogen and elevation of protein C and anti thrombin III. Changes in plasma lipids included significant reduction of HDL cholesterol associated with an increase in LDL triglycerides. No change occurred in total cholesterol. There were no major differences between the sexes, nor were there serious side effects.The effects of stanozolol on extrinsic (tissue-type) plasminogen activator activity, “free” plasminogen, protein C and antithrombin III, argue strongly in favour of its therapeutic potential.

Bibliography

Kluft, C., Preston, F. E., Malia, R. G., Bertina, R. M., Wijngaards, G., Greaves, M., Verheijen, J. H., & Dooijewaard, G. (1984). Stanozolol-Induced Changes in Fibrinolysis and Coagulation in Healthy Adults. Thrombosis and Haemostasis, 51(02), 157â164.

Authors 8

C Kluft (additional)
F E Preston (additional)
R G Malia (additional)
R M Bertina (additional)
G Wijngaards (additional)
M Greaves (additional)
J H Verheijen (additional)
G Dooijewaard (additional)

References 0 Referenced 50

None

Dates

Type	When
Created	7 years, 1 month ago (July 19, 2018, 6:33 p.m.)
Deposited	5 years, 9 months ago (Dec. 5, 2019, 10:16 a.m.)
Indexed	1 week, 1 day ago (Aug. 28, 2025, 8:03 a.m.)
Issued	41 years, 8 months ago (Jan. 1, 1984)
Published	41 years, 8 months ago (Jan. 1, 1984)
Published Online	7 years, 1 month ago (July 19, 2018)
Published Print	41 years, 8 months ago (Jan. 1, 1984)

Funders 0

None

BibTeX

@article{Kluft_1984, title={Stanozolol-Induced Changes in Fibrinolysis and Coagulation in Healthy Adults}, volume={51}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1661049}, DOI={10.1055/s-0038-1661049}, number={02}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Kluft, C and Preston, F E and Malia, R G and Bertina, R M and Wijngaards, G and Greaves, M and Verheijen, J H and Dooijewaard, G}, year={1984}, pages={157–164} }

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