DOI: 10.1055/s-0038-1657202. Protein C Deficiency in a Dutch Family with Thrombotic Disease

Protein C Deficiency in a Dutch Family with Thrombotic Disease

10.1055/s-0038-1657202

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryA rabbit antibody against human protein C was used for the quantitative estimation of protein C in plasma. In healthy individuals protein C antigen ranged from 0.65-1.45 U/ml. Plasma protein C antigen was found to be independent of either age or sex. Under influence of oral anticoagulant treatment the protein C antigen concentration decreased to 0.47 U/ml (at low intensity treatment) or 0.33 U/ml (at high intensity treatment). Using normal ranges of protein C and protein C/factor II and protein C/factor X ratios criteria were developed for the assessment of protein C deficiency. In a Dutch family with a history of thrombotic disease two members were found to have an isolated protein C deficiency, while a third one is suspected of protein C deficiency. In one case it was possible to confirm the diagnosis of suspected protein C deficiency during temporary withdrawal of the anticoagulant therapy.

Bibliography

Bertina, R. M., Broekmans, A. W., van der Linden, I. K., & Mertens, K. (1982). Protein C Deficiency in a Dutch Family with Thrombotic Disease. Thrombosis and Haemostasis, 48(01), 001â005.

Authors 4

R M Bertina (additional)
A W Broekmans (additional)
I K van der Linden (additional)
K Mertens (additional)

References 0 Referenced 183

None

Dates

Type	When
Created	7 years, 1 month ago (July 13, 2018, 6:38 p.m.)
Deposited	5 years, 8 months ago (Dec. 4, 2019, 4:34 p.m.)
Indexed	11 months, 1 week ago (Sept. 15, 2024, 3:56 p.m.)
Issued	43 years, 7 months ago (Jan. 1, 1982)
Published	43 years, 7 months ago (Jan. 1, 1982)
Published Online	7 years, 1 month ago (July 13, 2018)
Published Print	43 years, 7 months ago (Jan. 1, 1982)

Funders 0

None

BibTeX

@article{Bertina_1982, title={Protein C Deficiency in a Dutch Family with Thrombotic Disease}, volume={48}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1657202}, DOI={10.1055/s-0038-1657202}, number={01}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Bertina, R M and Broekmans, A W and van der Linden, I K and Mertens, K}, year={1982}, pages={001–005} }

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