DOI: 10.1055/s-0038-1655041. The Enigma of Severe Factor XI Deficiency without Hemorrhagic Symptoms

The Enigma of Severe Factor XI Deficiency without Hemorrhagic Symptoms

10.1055/s-0038-1655041

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryA case of very severe P. T. A. deficiency without hemorrhagic symptoms is described, and the possibility that the absence of a bleeding diathesis may have an explanation in the presently unknown interrelationship between 3 “contact phase” coagulation factors is suggested. The existence of “Fletcher factor” deficiency as an entity distinct from factor XI and XII deficiency is confirmed. The problems in establishing a diagnosis of P. T. A. deficiency are discussed. The authors believe that assay using known congenitally deficient plasma is the only certain method of diagnosing P. T. A. deficiency. The 3 members of the propositus’s family have minor P. T. A. deficiency, and the mode of inheritance in this family is consistent with the hypothesis of Rapaport et al.

Bibliography

Edson, J. R., White, J. G., & Krivit, W. (1967). The Enigma of Severe Factor XI Deficiency without Hemorrhagic Symptoms. Thrombosis and Haemostasis, 18(03/04), 342â348.

Authors 3

J. R Edson (additional)
J. G White (additional)
W Krivit (additional)

References 0 Referenced 11

None

Dates

Type	When
Created	7 years, 1 month ago (June 26, 2018, 2:36 p.m.)
Deposited	5 years, 8 months ago (Dec. 4, 2019, 3:32 p.m.)
Indexed	6 months ago (Feb. 21, 2025, 6:35 a.m.)
Issued	58 years, 7 months ago (Jan. 1, 1967)
Published	58 years, 7 months ago (Jan. 1, 1967)
Published Online	7 years, 2 months ago (June 26, 2018)
Published Print	58 years, 7 months ago (Jan. 1, 1967)

Funders 3

Minnesota Chapter of the National Hemophilia Foundation, the Minnesota Heart Association, the Graduate School of the University of Minnesota, the American Cancer Society, the Public Health Service
National Cancer Institute 10.13039/100000054
Region: Americas
gov (National government)
Labels4
1. Instituto Nacional del Cáncer
2. National Cancer Institute at the National Institutes of Health
3. Instituto Nacional del Cáncer de los Institutos Nacionales de la Salud
4. NCI
Awards1
1. CA08832
Public Health Service Research
Awards1
1. AM02917

BibTeX

@article{Edson_1967, title={The Enigma of Severe Factor XI Deficiency without Hemorrhagic Symptoms: Distinction from Hageman Factor and “Fletcher Factor” Deficiency; Family Study; and Problems of Diagnosis}, volume={18}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1655041}, DOI={10.1055/s-0038-1655041}, number={03/04}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Edson, J. R and White, J. G and Krivit, W}, year={1967}, pages={342–348} }

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