DOI: 10.1055/s-0038-1649595. A Comparative Analysis of D-Dimer Assays in Patients with Clinically Suspected Pulmonary Embolism

A Comparative Analysis of D-Dimer Assays in Patients with Clinically Suspected Pulmonary Embolism

10.1055/s-0038-1649595

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryTo avoid angiography in patients with clinically suspected pulmonary embolism and non-diagnostic lung scan results, the use of D-dimer has been advocated. We assessed plasma samples of 151 consecutive patients with clinically suspected pulmonary embolism. Lung scan results were: normal (43), high probability (48) and non-diagnostic (60; angiography performed in 43; 12 pulmonary emboli). Reproducibility, cut-off values, specificity, and percentage of patients in whom angiography could be avoided (with sensitivity 100%) were determined for two latex and four ELISA assays.The latex methods (cut-off 500 μg/1) agreed with corresponding ELISA tests in 83% (15% normal latex, abnormal ELISA) and 81% (7% normal latex, abnormal ELISA). ELISA methods showed considerable within- (2–17%) and between-assay Variation (12–26%). Cut-off values were 25 μg/l (Behring), 50 μg/l (Agen), 300 μg/l (Stago) and 550 μg/l (Organon). Specificity was 14–38%; in 4–15% of patients angiography could be avoided.We conclude that latex D-dimer assays appear not useful, whereas ELISA methods may be of limited value in the exclusion of pulmonary embolism.

Bibliography

van Beek, E. J. R., van den Ende, B., Berckmans, R. J., van der Heide, Y. T., Brandjes, D. P. M., Sturk, A., & ten Cate, J. W. (1993). A Comparative Analysis of D-Dimer Assays in Patients with Clinically Suspected Pulmonary Embolism. Thrombosis and Haemostasis, 70(03), 408â413.

Authors 7

Edwin J R van Beek (additional)
Bram van den Ende (additional)
René J Berckmans (additional)
Yvonne T van der Heide (additional)
Dees P M Brandjes (additional)
Augueste Sturk (additional)
Jan W ten Cate (additional)

References 0 Referenced 47

None

Dates

Type	When
Created	7 years, 1 month ago (July 5, 2018, 2:36 p.m.)
Deposited	5 years, 8 months ago (Dec. 4, 2019, 8:39 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 8, 2024, 12:43 a.m.)
Issued	32 years, 7 months ago (Jan. 1, 1993)
Published	32 years, 7 months ago (Jan. 1, 1993)
Published Online	7 years, 1 month ago (July 5, 2018)
Published Print	32 years, 7 months ago (Jan. 1, 1993)

Funders 0

None

BibTeX

@article{van_Beek_1993, title={A Comparative Analysis of D-Dimer Assays in Patients with Clinically Suspected Pulmonary Embolism}, volume={70}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1649595}, DOI={10.1055/s-0038-1649595}, number={03}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={van Beek, Edwin J R and van den Ende, Bram and Berckmans, René J and van der Heide, Yvonne T and Brandjes, Dees P M and Sturk, Augueste and ten Cate, Jan W}, year={1993}, pages={408–413} }

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