DOI: 10.1055/s-0038-1648653. Evidence that Calcium Regulates Platelet Function

Evidence that Calcium Regulates Platelet Function

10.1055/s-0038-1648653

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryIt is generally believed that calcium ions play a key role in regulation of platelet function.This is based on 3 types of evidence.1. Analogies with other cells. Calcium ions are known to trigger secretion and contraction in many cells, possibly reflecting a general role for calcium in all secretion and contraction.2. Indirect evidence. Platelet aggregation and secretion are induced by divalent cation ionophores. The response to the ionophore A23187 is identical to that induced by other potent stimuli.3. Direct evidence. Platelet activation can be blocked by drugs (e. g. certain local anesthetics) that block release of calcium ions from sarcoplasmic reticulum; the inhibition can be overcome by addition of extracellular calcium in the presence of a calcium ionophore. While this does not constitute definitive proof, the central role for calcium ions remains an attractive hypothesis that justifies attempts to further define calcium pools and fluxes in platelets.

Bibliography

Detwiler, T. C., Charo, I. F., & Feinman, R. D. (1978). Evidence that Calcium Regulates Platelet Function. Thrombosis and Haemostasis, 40(02), 207â211.

Authors 3

Thomas C Detwiler (additional)
Israel F Charo (additional)
Richard D Feinman (additional)

References 0 Referenced 100

None

Dates

Type	When
Created	7 years, 1 month ago (July 12, 2018, 6:35 p.m.)
Deposited	5 years, 8 months ago (Dec. 5, 2019, 8:58 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 10, 2024, 7:09 p.m.)
Issued	47 years, 8 months ago (Jan. 1, 1978)
Published	47 years, 8 months ago (Jan. 1, 1978)
Published Online	7 years, 1 month ago (July 12, 2018)
Published Print	47 years, 8 months ago (Jan. 1, 1978)

Funders 0

None

BibTeX

@article{Detwiler_1978, title={Evidence that Calcium Regulates Platelet Function}, volume={40}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0038-1648653}, DOI={10.1055/s-0038-1648653}, number={02}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Detwiler, Thomas C and Charo, Israel F and Feinman, Richard D}, year={1978}, pages={207–211} }

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