DOI: 10.1055/s-0037-1615964. The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

10.1055/s-0037-1615964

Crossref journal-article

Georg Thieme Verlag KG

Thrombosis and Haemostasis (194)

Abstract

SummaryThrombin generation has been studied in the plasma of severely factor XI deficient patients under conditions in which contact activation did not play a role. In platelet-rich as well as platelet-poor plasma, thrombin generation was dependent upon the presence of factor XI at tissue factor concentrations of between 1 and 20 pg/ml i.e. ~ 0.01 to 0.20% of the concentration normally present in the thromboplastin time determination. The requirement for factor XI is low; significant thrombin generation was seen at 1% factor XI; at 10%, thrombin formation was nearly normalised. A suspension of normal platelets in severely factor XI deficient plasma did not increase thrombin generation. This implies that there is no significant factor XI activity carried by normal platelets, although the presence of factor XI and factor XI inhibitors in platelets cannot be ruled out.

Bibliography

Keularts, I., Zivelin, A., Seligsohn, U., Hemker, H. C., & BÃ©guin, S. (2001). The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor. Thrombosis and Haemostasis, 85(06), 1060â1065.

Authors 5

Irene Keularts (first)
Ariella Zivelin (first)
Uri Seligsohn (first)
H. Coenraad Hemker (first)
Suzette Béguin (additional)

References 0 Referenced 75

None

Dates

Type	When
Created	7 years, 5 months ago (March 20, 2018, 3:11 a.m.)
Deposited	7 years, 5 months ago (March 20, 2018, 3:12 a.m.)
Indexed	1 year, 3 months ago (May 22, 2024, 2:36 p.m.)
Issued	24 years, 7 months ago (Jan. 1, 2001)
Published	24 years, 7 months ago (Jan. 1, 2001)
Published Online	7 years, 8 months ago (Dec. 12, 2017)
Published Print	24 years, 7 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Keularts_2001, title={The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor}, volume={85}, ISSN={2567-689X}, url={http://dx.doi.org/10.1055/s-0037-1615964}, DOI={10.1055/s-0037-1615964}, number={06}, journal={Thrombosis and Haemostasis}, publisher={Georg Thieme Verlag KG}, author={Keularts, Irene and Zivelin, Ariella and Seligsohn, Uri and Hemker, H. Coenraad and Béguin, Suzette}, year={2001}, pages={1060–1065} }

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