DOI: 10.1046/j.1600-0854.2003.00145.x. HIV‐1 Egress is Gated Through Late Endosomal Membranes

HIV‐1 Egress is Gated Through Late Endosomal Membranes

10.1046/j.1600-0854.2003.00145.x

Crossref journal-article

Wiley

Traffic (311)

Abstract

HIV‐1 buds from the surface of activated T lymphocytes. In macrophages, however, newly formed HIV‐1 particles amass in the lumen of an intracellular compartment. Here, we demonstrate by live‐cell imaging techniques, by immunocytochemistry and by immuno‐electron microscopy that HIV‐1 structural proteins, particularly the internal structural protein Gag, accumulate at membranes of the late endocytic compartment in a variety of cell types and not just in monocyte/macrophage‐derived cells. Recent biochemical and genetic studies have implicated components of the mammalian vacuolar protein sorting pathway in retroviral budding. Together with those observations, our study suggests that HIV‐1 morphogenesis is thoroughly rooted in the endosomal system.

Bibliography

Nydegger, S., Foti, M., Derdowski, A., Spearman, P., & Thali, M. (2003). HIVâ1 Egress is Gated Through Late Endosomal Membranes. Traffic, 4(12), 902â910. Portico.

Authors 5

Sascha Nydegger (first)
Michelangelo Foti (additional)
Aaron Derdowski (additional)
Paul Spearman (additional)
Markus Thali (additional)

References 55 Referenced 155

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Dates

Type	When
Created	21 years, 9 months ago (Nov. 17, 2003, 2:45 a.m.)
Deposited	1 year, 10 months ago (Oct. 14, 2023, 2:34 a.m.)
Indexed	11 months, 3 weeks ago (Aug. 29, 2024, 4:59 a.m.)
Issued	21 years, 9 months ago (Nov. 16, 2003)
Published	21 years, 9 months ago (Nov. 16, 2003)
Published Online	21 years, 9 months ago (Nov. 16, 2003)
Published Print	21 years, 8 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Nydegger_2003, title={HIV‐1 Egress is Gated Through Late Endosomal Membranes}, volume={4}, ISSN={1600-0854}, url={http://dx.doi.org/10.1046/j.1600-0854.2003.00145.x}, DOI={10.1046/j.1600-0854.2003.00145.x}, number={12}, journal={Traffic}, publisher={Wiley}, author={Nydegger, Sascha and Foti, Michelangelo and Derdowski, Aaron and Spearman, Paul and Thali, Markus}, year={2003}, month=nov, pages={902–910} }

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