DOI: 10.1046/j.1474-9728.2003.00043.x. Transcriptional outputs of the <i>Caenorhabditis elegans</i> forkhead protein DAF‐16

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16

10.1046/j.1474-9728.2003.00043.x

Crossref journal-article

Wiley

Aging Cell (311)

Abstract

SummaryIn Caenorhabditis elegans, the forkhead protein DAF‐16 transduces insulin‐like signals that regulate larval development and adult lifespan. To identify DAF‐16‐dependent transcriptional alterations that occur in a long‐lived C. elegans strain, we used cDNA microarrays and genomic analysis to identify putative direct and indirect DAF‐16 transcriptional target genes. Our analysis suggests that DAF‐16 action regulates a wide range of physiological responses by altering the expression of genes involved in metabolism, energy generation and cellular stress responses. Furthermore, we observed a large overlap between DAF‐16‐dependent transcription and genes normally expressed in the long‐lived dauer larval stage. Finally, we examined the in vivo role of 35 of these target genes by RNA‐mediated interference and identified one gene encoding a putative protease that is necessary for the daf‐2 Age phenotype.

Bibliography

McElwee, J., Bubb, K., & Thomas, J. H. (2003). Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAFâ16. Aging Cell, 2(2), 111â121. Portico.

Authors 3

Joshua McElwee (first)
Kerry Bubb (additional)
James H. Thomas (additional)

References 62 Referenced 346

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Dates

Type	When
Created	20 years, 8 months ago (Dec. 17, 2004, 12:48 p.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 12:48 p.m.)
Indexed	54 minutes ago (Sept. 3, 2025, 11:42 p.m.)
Issued	22 years, 5 months ago (March 26, 2003)
Published	22 years, 5 months ago (March 26, 2003)
Published Online	22 years, 5 months ago (March 26, 2003)
Published Print	22 years, 5 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{McElwee_2003, title={Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16}, volume={2}, ISSN={1474-9726}, url={http://dx.doi.org/10.1046/j.1474-9728.2003.00043.x}, DOI={10.1046/j.1474-9728.2003.00043.x}, number={2}, journal={Aging Cell}, publisher={Wiley}, author={McElwee, Joshua and Bubb, Kerry and Thomas, James H.}, year={2003}, month=mar, pages={111–121} }

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    "1474-9718",
    "1474-9726"
  ],
  "subject": [],
  "container-title-short": "Aging Cell",
  "published": {
    "date-parts": [
      [
        2003,
        3,
        26
      ]
    ]
  }
}