DOI: 10.1046/j.1471-4159.2004.02329.x. Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both<i>in vitro</i>and<i>in vivo</i>

Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells bothin vitroandin vivo

10.1046/j.1471-4159.2004.02329.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

AbstractLithium has been demonstrated to increase neurogenesis in the dentate gyrus of rodent hippocampus. The present study was undertaken to investigate the effects of lithium on the proliferation and differentiation of rat neural progenitor cells in hippocampus bothin vitroandin vivo. Lithium chloride (1–3 mm) produced a significant increase in the number of bromodeoxyuridine (BrdU)‐positive cells in high‐density cultures, but did not increase clonal size in low‐density cultures. Lithium chloride at 1 mm(within the therapeutic range) also increased the number of cells double‐labeled with BrdU antibody and TuJ1 (a class III β‐tubulin antibody) in high‐density cultures and the number of TuJ1‐positive cells in a clone of low‐density cultures, whereas it decreased the number of glial fibrillary acidic protein‐positive cells in both cultures. These results suggest that lithium selectively increased differentiation of neuronal progenitors. These actions of lithium appeared to enhance a neuronal subtype, calbindinD28k‐positive cells, and involved a phosphorylated extracellular signal‐regulated kinase and phosphorylated cyclic AMP response element‐binding protein‐dependent pathway bothin vitroandin vivo. These findings suggest that lithium in therapeutic amounts may elicit its beneficial effects via facilitation of neural progenitor differentiation toward a calbindinD28k‐positive neuronal cell type.

Bibliography

Kim, J. S., Chang, M., Yu, I. T., Kim, J. H., Lee, S., Lee, Y., & Son, H. (2004). Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells bothin vitroandin vivo. Journal of Neurochemistry, 89(2), 324â336. Portico.

Authors 7

Jin Seuk Kim (first)
Mi‐Yoon Chang (additional)
In Tag Yu (additional)
Ju Hee Kim (additional)
Sang‐Hun Lee (additional)
Yong‐Sung Lee (additional)
Hyeon Son (additional)

References 43 Referenced 147

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{'key': 'e_1_2_20_26_1', 'first-page': '82', 'article-title': 'Lithium upregulates the cytoprotective protein bcl‐2 in vitro and in the CNS in vivo: a role of neurotrophic and neuroprotective effects in manic‐depressive illness', 'volume': '61', 'author': 'Manji H. K.', 'year': '2000', 'journal-title': 'J. Clin. Psychiatry'} / J. Clin. Psychiatry / Lithium upregulates the cytoprotective protein bcl‐2 in vitro and in the CNS in vivo: a role of neurotrophic and neuroprotective effects in manic‐depressive illness by Manji H. K. (2000)
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Dates

Type	When
Created	18 years, 11 months ago (Sept. 21, 2006, 5:35 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 2:08 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 11, 2024, 11:07 p.m.)
Issued	21 years, 5 months ago (March 22, 2004)
Published	21 years, 5 months ago (March 22, 2004)
Published Online	21 years, 5 months ago (March 22, 2004)
Published Print	21 years, 5 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Kim_2004, title={Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells bothin vitroandin vivo}, volume={89}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.2004.02329.x}, DOI={10.1046/j.1471-4159.2004.02329.x}, number={2}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Kim, Jin Seuk and Chang, Mi‐Yoon and Yu, In Tag and Kim, Ju Hee and Lee, Sang‐Hun and Lee, Yong‐Sung and Son, Hyeon}, year={2004}, month=mar, pages={324–336} }

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