DOI: 10.1046/j.1471-4159.1999.720879.x. The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

10.1046/j.1471-4159.1999.720879.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract : Differential display of mRNA was used to identify concordant changes in gene expression induced by two mood‐stabilizing agents, lithium and valproate (VPA). Both treatments, on chronic administration, increased mRNA levels of the transcription factor polyomavirus enhancer‐binding protein (PEBP) 2β in frontal cortex (FCx). Both treatments also increased the DNA binding activity of PEBP2αβ and robustly increased the levels of bcl‐2 (known to be transcriptionally regulated by PEBP2) in FCx. Immunohistochemical studies revealed a marked increase in the number of bcl‐2‐immunoreactive cells in layers 2 and 3 of FCx. These novel findings represent the first report of medication‐induced increases in CNS bcl‐2 levels and may have implications not only for mood disorders, but also for long‐term treatment of various neurodegenerative disorders.

Bibliography

Chen, G., Zeng, W., Yuan, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K. (1999). The MoodâStabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bclâ2 in the CNS. Journal of Neurochemistry, 72(2), 879â882. Portico.

Authors 7

Guang Chen (first)
Wei‐Zhang Zeng (additional)
Pei‐Xiong Yuan (additional)
Li‐Dong Huang (additional)
Yi‐Ming Jiang (additional)
Zhen‐Hua Zhao (additional)
Husseini K. Manji (additional)

References 24 Referenced 402

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Dates

Type	When
Created	22 years, 5 months ago (March 12, 2003, 1:36 a.m.)
Deposited	1 year, 10 months ago (Oct. 29, 2023, 2:07 p.m.)
Indexed	4 weeks ago (Aug. 5, 2025, 8:56 a.m.)
Issued	26 years, 7 months ago (Feb. 1, 1999)
Published	26 years, 7 months ago (Feb. 1, 1999)
Published Online	23 years, 2 months ago (June 13, 2002)
Published Print	26 years, 7 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Chen_1999, title={The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS}, volume={72}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.1999.720879.x}, DOI={10.1046/j.1471-4159.1999.720879.x}, number={2}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Chen, Guang and Zeng, Wei‐Zhang and Yuan, Pei‐Xiong and Huang, Li‐Dong and Jiang, Yi‐Ming and Zhao, Zhen‐Hua and Manji, Husseini K.}, year={1999}, month=feb, pages={879–882} }

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