DOI: 10.1046/j.1471-4159.1999.0722053.x. p38 Kinase Is Activated in the Alzheimer's Disease Brain

p38 Kinase Is Activated in the Alzheimer's Disease Brain

10.1046/j.1471-4159.1999.0722053.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age‐matched normal brain. Intense phospho‐p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle‐bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF‐positive tau did not cross‐react with the phospho‐p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.

Bibliography

Hensley, K., Floyd, R. A., Zheng, N., Nael, R., Robinson, K. A., Nguyen, X., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., Patel, E., Johnson, G. V. W., & Bing, G. (1999). p38 Kinase Is Activated in the Alzheimerâs Disease Brain. Journal of Neurochemistry, 72(5), 2053â2058. Portico.

Authors 13

Kenneth Hensley (first)
Robert A. Floyd (additional)
Nai‐Ying Zheng (additional)
Raha Nael (additional)
Kent A. Robinson (additional)
Xuan Nguyen (additional)
Quentin N. Pye (additional)
Charles A. Stewart (additional)
James Geddes (additional)
William R. Markesbery (additional)
Ela Patel (additional)
Gail V. W. Johnson (additional)
Guoying Bing (additional)

References 22 Referenced 306

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{'key': 'e_1_2_2_10_1', 'article-title': 'Activation of mitogen‐activated protein kinase by H2O2', 'volume': '4142', 'author': 'Guyton K. Z.', 'year': '1996', 'journal-title': 'Role in cell survival following oxidant'} / Role in cell survival following oxidant / Activation of mitogen‐activated protein kinase by H2O2 by Guyton K. Z. (1996)
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10.1046/j.1471-4159.1997.69010191.x
10.1212/WNL.45.1.51
10.4049/jimmunol.158.7.3165 / J. Immunol. / Actions of IL‐1 are selectively controlled by p38 mitogen‐activated protein kinase by Ridley S. H. (1997)
10.1002/(SICI)1097-4547(19990315)55:6<724::AID-JNR7>3.0.CO;2-9 / J. Neurosci. Res. / Redox‐sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture by Robinson K. A. (1999)
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10.1056/NEJM199704243361704
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Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 8:39 p.m.)
Deposited	1 year, 10 months ago (Oct. 29, 2023, 2:46 a.m.)
Indexed	4 weeks, 2 days ago (Aug. 3, 2025, 7:05 p.m.)
Issued	26 years, 4 months ago (May 1, 1999)
Published	26 years, 4 months ago (May 1, 1999)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	26 years, 4 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Hensley_1999, title={p38 Kinase Is Activated in the Alzheimer’s Disease Brain}, volume={72}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.1999.0722053.x}, DOI={10.1046/j.1471-4159.1999.0722053.x}, number={5}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Hensley, Kenneth and Floyd, Robert A. and Zheng, Nai‐Ying and Nael, Raha and Robinson, Kent A. and Nguyen, Xuan and Pye, Quentin N. and Stewart, Charles A. and Geddes, James and Markesbery, William R. and Patel, Ela and Johnson, Gail V. W. and Bing, Guoying}, year={1999}, month=may, pages={2053–2058} }

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