DOI: 10.1046/j.1471-4159.1998.71062642.x. Increased Vulnerability to 3‐Nitropropionic Acid in an Animal Model of Huntington's Disease

Increased Vulnerability to 3‐Nitropropionic Acid in an Animal Model of Huntington's Disease

10.1046/j.1471-4159.1998.71062642.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: There is substantial evidence for both metabolic dysfunction and oxidative damage in Huntington's disease (HD). In the present study, we used in vivo microdialysis to measure the conversion of 4‐hydroxybenzoic acid to 3,4‐dihydroxybenzoic acid (3,4‐DHBA) as a measure of hydroxyl radical production in a transgenic mouse model of HD, as well as in littermate controls. The conversion of 4‐hydroxybenzoic acid to 3,4‐DHBA was unchanged in the striatum of transgenic HD mice at baseline. Following administration of the mitochondrial toxin 3‐nitropropionic acid (3‐NP), there were significant increases in 3,4‐DHBA generation in both control and transgenic HD mice, and the increases in the transgenic HD mice were significantly greater than those in controls. Furthermore, administration of 3‐NP produced significantly larger striatal lesions in transgenic HD mice than in littermate controls. The present results show increased sensitivity to the mitochondrial toxin 3‐NP in transgenic HD mice, which suggests metabolic dysfunction in this mouse model of HD.

Bibliography

Bogdanov, M. B., Ferrante, R. J., Kuemmerle, S., Klivenyi, P., & Beal, M. F. (1998). Increased Vulnerability to 3âNitropropionic Acid in an Animal Model of Huntingtonâs Disease. Journal of Neurochemistry, 71(6), 2642â2644. Portico.

Authors 5

Mikhail B. Bogdanov (first)
Robert J. Ferrante (additional)
Stefan Kuemmerle (additional)
Peter Klivenyi (additional)
M. Flint Beal (additional)

References 0 Referenced 69

None

Dates

Type	When
Created	15 years, 1 month ago (July 16, 2010, 1:41 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 8:21 p.m.)
Indexed	1 year, 1 month ago (July 21, 2024, 4:29 a.m.)
Issued	26 years, 9 months ago (Dec. 1, 1998)
Published	26 years, 9 months ago (Dec. 1, 1998)
Published Online	22 years, 9 months ago (Nov. 13, 2002)
Published Print	26 years, 9 months ago (Dec. 1, 1998)

Funders 0

None

BibTeX

@article{Bogdanov_1998, title={Increased Vulnerability to 3‐Nitropropionic Acid in an Animal Model of Huntington’s Disease}, volume={71}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.1998.71062642.x}, DOI={10.1046/j.1471-4159.1998.71062642.x}, number={6}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Bogdanov, Mikhail B. and Ferrante, Robert J. and Kuemmerle, Stefan and Klivenyi, Peter and Beal, M. Flint}, year={1998}, month=dec, pages={2642–2644} }

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