DOI: 10.1046/j.1471-4159.1994.63041576.x. Are Striatal Dopamine D<sub>4</sub> Receptors Increased in Schizophrenia?

Are Striatal Dopamine D4 Receptors Increased in Schizophrenia?

10.1046/j.1471-4159.1994.63041576.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract: The density of dopamine D2‐like receptors was determined using [3H]emonapride binding in putamen tissue taken postmortem from schizophrenic subjects and matched controls. A 72% increase in number of these receptors was identified in the schizophrenics, although three patients not receiving antipsychotic drug treatment before death exhibited receptor densities in the control range. Displacement of 1 nM [3H]emonapride binding by raclopride was used to define the contribution of the D4 subtype of dopamine receptors to total [3H]emonapride binding. No evidence was obtained for the presence of D4 receptors in putamen tissue from either control or schizophrenic subjects, indicating that the increase in D2‐like receptor density in schizophrenia is due not to an increase in number of D4 sites in the disease, but to an up‐regulation of D2 or D3 receptors probably induced by chronic treatment with antipsychotic drugs.

Bibliography

Reynolds, G. P., & Mason, S. L. (1994). Are Striatal Dopamine D4 Receptors Increased in Schizophrenia? Journal of Neurochemistry, 63(4), 1576â1577. Portico.

Authors 2

Gavin P. Reynolds (first)
Sarah L. Mason (additional)

References 0 Referenced 78

None

Dates

Type	When
Created	15 years, 1 month ago (July 15, 2010, 6:28 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 8:55 p.m.)
Indexed	2 months, 2 weeks ago (June 12, 2025, 5:44 a.m.)
Issued	30 years, 10 months ago (Oct. 1, 1994)
Published	30 years, 10 months ago (Oct. 1, 1994)
Published Online	22 years, 9 months ago (Nov. 23, 2002)
Published Print	30 years, 10 months ago (Oct. 1, 1994)

Funders 0

None

BibTeX

@article{Reynolds_1994, title={Are Striatal Dopamine D4 Receptors Increased in Schizophrenia?}, volume={63}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.1994.63041576.x}, DOI={10.1046/j.1471-4159.1994.63041576.x}, number={4}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Reynolds, Gavin P. and Mason, Sarah L.}, year={1994}, month=oct, pages={1576–1577} }

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