DOI: 10.1046/j.1471-4159.1994.62031223.x. The Quantity of Calcium that Appears to Induce Neuronal Death

The Quantity of Calcium that Appears to Induce Neuronal Death

10.1046/j.1471-4159.1994.62031223.x

Crossref journal-article

Wiley

Journal of Neurochemistry (311)

Abstract

Abstract:Excessive entry of Ca2+through the NMDA receptor is thought to be the major cause of glutamate toxicity in brain neurons. However, actual quantitation of the calcium overload has not been achieved. Here we show that the absolute amount of45Ca2+taken up via the NMDA receptor correlates quantitatively with the amount of acute cell death in cultured cerebellar granule cells of the rat. Analysis of 9‐and 16‐day cultures reveals that the NMDA‐induced Ca2+uptake is about the same at these ages, whereas the Ca‐dependent lethal process is more developed in the older neurons. The calculated lethal concentration of45Ca taken up exceeds by ∼10,000 times the maximal concentration of [Ca2+], that can be measured by fluorescence imaging. It is suggested that the Ca2+taken up induces the lethal process in a subcellular structure in which it has been segregated.

Bibliography

Eimerl, S., & Schramm, M. (1994). The Quantity of Calcium that Appears to Induce Neuronal Death. Journal of Neurochemistry, 62(3), 1223â1226. Portico.

Authors 2

Sara Eimerl (first)
Michael Schramm (additional)

References 16 Referenced 138

10.1016/S0021-9258(18)43551-X
{'key': 'e_1_2_1_3_1', 'first-page': '936', 'article-title': 'Evaluation of a tetrazolium‐based semiautomated colormetric assay: assessment of chemosensitivity testing', 'volume': '47', 'author': 'Carmichael J.', 'year': '1987', 'journal-title': 'Cancer Res.'} / Cancer Res. / Evaluation of a tetrazolium‐based semiautomated colormetric assay: assessment of chemosensitivity testing by Carmichael J. (1987)
10.1146/annurev.ne.13.030190.001131
10.1002/jnr.490270105
10.1523/JNEUROSCI.13-02-00623.1993
10.1016/0304-3940(92)90403-T
10.1111/j.1471-4159.1993.tb02154.x
{'key': 'e_1_2_1_9_1', 'first-page': '1501', 'article-title': 'The quantity of Ca that enters a neuron to cause its death in glutamate toxicity', 'volume': '19', 'author': 'Eimerl S.', 'year': '1993', 'journal-title': 'Soc Neurosci. Abstr.'} / Soc Neurosci. Abstr. / The quantity of Ca that enters a neuron to cause its death in glutamate toxicity by Eimerl S. (1993)
10.1111/j.1432-1033.1970.tb00912.x
10.1016/0304-3940(86)90256-9
10.1523/JNEUROSCI.13-05-01993.1993
10.1016/0028-3908(89)90004-X
10.1016/S0026-895X(25)09102-3 / Mol. Pharmacol. / Delayed increase of Ca2+ elicited by glutamate: role in neuronal death by Manev H. (1989)
10.1016/0165-6147(90)90184-A
10.1146/annurev.pa.32.040192.002313
10.1523/JNEUROSCI.12-05-01882.1992

Dates

Type	When
Created	15 years, 1 month ago (July 15, 2010, 6:05 p.m.)
Deposited	6 months, 1 week ago (Feb. 22, 2025, 6:21 p.m.)
Indexed	1 week, 3 days ago (Aug. 20, 2025, 8:55 a.m.)
Issued	31 years, 5 months ago (March 1, 1994)
Published	31 years, 5 months ago (March 1, 1994)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	31 years, 5 months ago (March 1, 1994)

Funders 0

None

BibTeX

@article{Eimerl_1994, title={The Quantity of Calcium that Appears to Induce Neuronal Death}, volume={62}, ISSN={1471-4159}, url={http://dx.doi.org/10.1046/j.1471-4159.1994.62031223.x}, DOI={10.1046/j.1471-4159.1994.62031223.x}, number={3}, journal={Journal of Neurochemistry}, publisher={Wiley}, author={Eimerl, Sara and Schramm, Michael}, year={1994}, month=mar, pages={1223–1226} }

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