DOI: 10.1046/j.1464-410x.2002.02848.x. Technical characterization of an ultrasound source for noninvasive thermoablation by high‐intensity focused ultrasound

Technical characterization of an ultrasound source for noninvasive thermoablation by high‐intensity focused ultrasound

10.1046/j.1464-410x.2002.02848.x

Crossref journal-article

Wiley

BJU International (311)

Abstract

Objective To develop a generator for high‐intensity focused ultrasound (HIFU, a method of delivering ultrasonic energy with resultant heat and tissue destruction to a tight focus at a selected depth within the body), designed for extracorporeal coupling to allow various parenchymal organs to be treated. Material and methods The ultrasound generated by a cylindrical piezo‐ceramic element is focused at a depth of 10 cm using a parabolic reflector with a diameter of 10 cm. A diagnostic B‐mode ultrasonographic transducer is integrated into the source to allow the focus to be located in the target area. The field distribution of the sound pressure was measured in degassed water using a needle hydrophone. An ultrasound‐force balance was used to determine the acoustic power. These measurements allowed the spatially averaged sound intensity to be calculated. The morphology and extent of tissue necrosis induced by HIFU was examined on an ex‐vivo kidney model. Results The two‐dimensional field distribution resulted in an approximately ellipsoidal focus of 32×4 mm (− 6 dB). The spatially maximum averaged sound intensity was 8591 W/cm2 at an electrical power of 400 W. The lesion caused to the ex‐vivo kidney at this maximum generator power with a pulse duration of 2 s was a clearly delineated ellipsoidal coagulation necrosis up to 8.8×2.3 mm (length×width) and with central liquefied necrosis of 7.9×1.9 mm. Conclusion This newly developed ultrasound generator with a focal length of 10 cm can induce clear necrosis in parenchymal tissue. Because of its specific configuration and the available power range of the ultrasound generator, there is potential for therapeutic noninvasive ablation of tissue deep within a patient's body.

Bibliography

KÃ¶hrmann, K. U., Michel, M. S., Steidler, A., Marlinghaus, E., Kraut, O., & Alken, P. (2002). Technical characterization of an ultrasound source for noninvasive thermoablation by highâintensity focused ultrasound. BJU International, 90(3), 248â252. Portico.

Authors 6

K.U. Köhrmann (first)
M.S. Michel (additional)
A. Steidler (additional)
E. Marlinghaus (additional)
O. Kraut (additional)
P. Alken (additional)

References 14 Referenced 34

10.1109/IRET-ME.1960.5008041 / IRE Trans Med Electronics / Fundamental neurological research and human neurosurgery using intense ultrasound by Fry WJ (1960)
10.1159/000474671 / Eur Urol / Intense focused ultrasound in medicine by Fry FJ (1993)
10.1016/0301-5629(96)89519-6
{'key': 'e_1_2_5_2_4_2', 'first-page': '436', 'volume-title': 'Physical Principles of Medical Ultrasonics.', 'author': 'Ter Haar GR', 'year': '1986'} / Physical Principles of Medical Ultrasonics. by Ter Haar GR (1986)
10.1159/000474672 / Eur Urol / Tissue destruction with focused ultrasound in vivo by Ter Haar GR (1993)
10.3171/jns.1954.11.5.0471
{'key': 'e_1_2_5_2_7_2', 'first-page': '179', 'article-title': 'High‐intensity focused ultrasound in prostate cancer: results after 3 years', 'volume': '4', 'author': 'Chaussy C', 'year': '2000', 'journal-title': 'Mol Urol'} / Mol Urol / High‐intensity focused ultrasound in prostate cancer: results after 3 years by Chaussy C (2000)
10.1016/S0022-5347(01)62087-1
10.1089/end.1992.6.173
{'key': 'e_1_2_5_2_10_2', 'first-page': '17', 'article-title': 'Ultraschall‐Leistungsmessung mit Hilfe der Schallstrahlungskraft', 'volume': '58', 'author': 'Beissner K', 'year': '1985', 'journal-title': 'Acustica'} / Acustica / Ultraschall‐Leistungsmessung mit Hilfe der Schallstrahlungskraft by Beissner K (1985)
{'key': 'e_1_2_5_2_11_2', 'first-page': '259', 'article-title': 'Lesions development in focused ultrasound surgery: a general model', 'volume': '20', 'author': 'Hill CR', 'year': '1994', 'journal-title': 'UMB'} / UMB / Lesions development in focused ultrasound surgery: a general model by Hill CR (1994)
10.1121/1.1906542
10.1016/S0929-8266(99)00009-9
{'key': 'e_1_2_5_2_14_2', 'first-page': '3346', 'article-title': 'Effect of high‐intensity focused ultrasound on human prostate cancer in vivo', 'volume': '55', 'author': 'Madersbacher S', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Effect of high‐intensity focused ultrasound on human prostate cancer in vivo by Madersbacher S (1995)

Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 3:11 a.m.)
Deposited	1 year, 10 months ago (Oct. 17, 2023, 6:31 a.m.)
Indexed	4 months, 4 weeks ago (April 4, 2025, 1:45 p.m.)
Issued	23 years, 1 month ago (July 19, 2002)
Published	23 years, 1 month ago (July 19, 2002)
Published Online	23 years, 1 month ago (July 19, 2002)
Published Print	23 years, 1 month ago (Aug. 1, 2002)

Funders 0

None

BibTeX

@article{K_hrmann_2002, title={Technical characterization of an ultrasound source for noninvasive thermoablation by high‐intensity focused ultrasound}, volume={90}, ISSN={1464-410X}, url={http://dx.doi.org/10.1046/j.1464-410x.2002.02848.x}, DOI={10.1046/j.1464-410x.2002.02848.x}, number={3}, journal={BJU International}, publisher={Wiley}, author={Köhrmann, K.U. and Michel, M.S. and Steidler, A. and Marlinghaus, E. and Kraut, O. and Alken, P.}, year={2002}, month=jul, pages={248–252} }

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