DOI: 10.1046/j.1460-9568.2003.02830.x. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin‐like growth factor‐I in the dentate gyrus of adult female rat

An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin‐like growth factor‐I in the dentate gyrus of adult female rat

10.1046/j.1460-9568.2003.02830.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractInterdependence between estradiol and insulin‐like growth factor‐I has been documented for different neural events, including neuronal differentiation, synaptic plasticity, neuroendocrine regulation and neuroprotection. In the present study we have assessed whether both factors interact in the regulation of neurogenesis in the adult rat dentate gyrus. Wistar albino female rats were bilaterally ovariectomized and treated with estradiol, insulin‐like growth factor‐I and/or the estrogen receptor antagonist ICI 182,780. Estradiol was administered in a subcutaneous silastic capsule. Insulin‐like growth factor‐I and ICI 182,780 were delivered in the lateral cerebral ventricle. Animals received six daily injections of 5‐bromo‐2‐deoxyuridine and were killed 24 h after the last injection. The total number of 5‐bromo‐2‐deoxyuridine‐positive neurons was significantly increased in animals treated with insulin‐like growth factor‐I, compared with rats treated with vehicles, while rats treated with both insulin‐like growth factor‐I and estradiol showed a higher number of 5‐bromo‐2‐deoxyuridine‐positive neurons than rats treated with insulin‐like growth factor‐I or estradiol alone. The antiestrogen ICI 182,780 blocked the effect of insulin‐like growth factor‐I on the number of 5‐bromo‐2‐deoxyuridine neurons with independence of whether the animals were treated or not with estradiol. These findings suggest that estrogen receptors are involved in the induction of adult neurogenesis by insulin‐like growth factor‐I in the dentate gyrus, and that estradiol and insulin‐like growth factor‐I have a cooperative interaction to promote neurogenesis. The interaction between insulin‐like growth factor‐I and estradiol may participate in changes in the rate of neurogenesis during different endocrine and physiological conditions, and may be related to the decline in neurogenesis with ageing.

Bibliography

PerezâMartin, M., Azcoitia, I., Trejo, J. L., Sierra, A., & GarciaâSegura, L. M. (2003). An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulinâlike growth factorâI in the dentate gyrus of adult female rat. European Journal of Neuroscience, 18(4), 923â930. Portico.

Authors 5

Margarita Perez‐Martin (first)
Iñigo Azcoitia (additional)
Jose Luis Trejo (additional)
Amanda Sierra (additional)
Luis M. Garcia‐Segura (additional)

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Dates

Type	When
Created	22 years ago (Aug. 18, 2003, 11:24 a.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 3:39 p.m.)
Indexed	4 days, 1 hour ago (Sept. 3, 2025, 6:35 a.m.)
Issued	22 years, 1 month ago (Aug. 1, 2003)
Published	22 years, 1 month ago (Aug. 1, 2003)
Published Online	22 years ago (Aug. 12, 2003)
Published Print	22 years, 1 month ago (Aug. 1, 2003)

Funders 0

None

BibTeX

@article{Perez_Martin_2003, title={An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin‐like growth factor‐I in the dentate gyrus of adult female rat}, volume={18}, ISSN={1460-9568}, url={http://dx.doi.org/10.1046/j.1460-9568.2003.02830.x}, DOI={10.1046/j.1460-9568.2003.02830.x}, number={4}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Perez‐Martin, Margarita and Azcoitia, Iñigo and Trejo, Jose Luis and Sierra, Amanda and Garcia‐Segura, Luis M.}, year={2003}, month=aug, pages={923–930} }

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