DOI: 10.1046/j.1460-9568.2002.01985.x. Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

10.1046/j.1460-9568.2002.01985.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractThis paper focuses on high‐frequency (gamma band) EEG activity, the most characteristic electrophysiological pattern in focal seizures of human epilepsy. It starts with recent hypotheses about: (i) the behaviour of inhibitory interneurons in hippocampal or neocortical networks in the generation of gamma frequency oscillations; (ii) the nonuniform alteration of GABAergic inhibition in experimental epilepsy (reduced dendritic inhibition and increased somatic inhibition); and (iii) the possible depression of GABAA,fast circuit activity by GABAA,slow inhibitory postsynaptic currents. In particular, these hypotheses are introduced in a new computational macroscopic model of EEG activity that includes a physiologically relevant fast inhibitory feedback loop. Results show that strikingly realistic activity is produced by the model when compared to real EEG signals recorded with intracerebral electrodes. They show that, in the model, the transition from interictal to fast ictal activity is explained by the impairment of dendritic inhibition.

Bibliography

Wendling, F., Bartolomei, F., Bellanger, J. J., & Chauvel, P. (2002). Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition. European Journal of Neuroscience, 15(9), 1499â1508. Portico.

Authors 4

F. Wendling (first)
F. Bartolomei (additional)
J. J. Bellanger (additional)
P. Chauvel (additional)

References 23 Referenced 524

10.1016/0013-4694(92)90160-J
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10.1038/82900
10.1111/j.1528-1157.1997.tb05200.x
10.1016/0006-8993(91)90110-H
{'key': 'e_1_2_7_9_1', 'first-page': '9', 'article-title': 'Models of the dynamics of neural populations', 'volume': '34', 'author': 'Freeman W.J.', 'year': '1978', 'journal-title': 'Electroencephalogr. Clin. Neurophysiol.'} / Electroencephalogr. Clin. Neurophysiol. / Models of the dynamics of neural populations by Freeman W.J. (1978)
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Dates

Type	When
Created	22 years, 5 months ago (March 6, 2003, 9:47 a.m.)
Deposited	1 year, 10 months ago (Oct. 3, 2023, 12:01 a.m.)
Indexed	3 days, 12 hours ago (Aug. 26, 2025, 2:34 a.m.)
Issued	23 years, 3 months ago (May 1, 2002)
Published	23 years, 3 months ago (May 1, 2002)
Published Online	23 years, 3 months ago (May 22, 2002)
Published Print	23 years, 3 months ago (May 1, 2002)

Funders 0

None

BibTeX

@article{Wendling_2002, title={Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition}, volume={15}, ISSN={1460-9568}, url={http://dx.doi.org/10.1046/j.1460-9568.2002.01985.x}, DOI={10.1046/j.1460-9568.2002.01985.x}, number={9}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Wendling, F. and Bartolomei, F. and Bellanger, J. J. and Chauvel, P.}, year={2002}, month=may, pages={1499–1508} }

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