DOI: 10.1046/j.1440-1711.2001.00975.x. Migration of Langerhans cells and γδ<sup>+</sup> dendritic cells from UV‐B‐irradiated sheep skin

Migration of Langerhans cells and γδ+ dendritic cells from UV‐B‐irradiated sheep skin

10.1046/j.1440-1711.2001.00975.x

Crossref journal-article

Wiley

Immunology & Cell Biology (311)

Abstract

Depletion of dendritic cells from UV‐B‐irradiated sheep skin was investigated by monitoring migration of these cells towards regional lymph nodes. By creating and cannulating pseudoafferent lymphatic vessels draining a defined region of skin, migrating cells were collected and enumerated throughout the response to UV‐B irradiation. In the present study, the effects of exposing sheep flank skin to UV‐B radiation clearly demonstrated a dose‐dependent increase in the migration of Langerhans cells (LC) from the UV‐B‐exposed area to the draining lymph node. The range of UV‐B doses assessed in this study included 2.7 kJ/m2, a suberythemal dose; 8 kJ/m2, 1 minimal erythemal dose (MED); 20.1 kJ/m2; 40.2 kJ/m2; and 80.4 kJ/m2, 10 MED. The LC were the cells most sensitive to UV‐B treatment, with exposure to 8 kJ/m2 or greater reproducibly causing a significant increase in migration. Migration of γδ+ dendritic cells (γδ+ DC) from irradiated skin was also triggered by exposure to UV‐B radiation, but dose dependency was not evident within the range of UV‐B doses examined. This, in conjunction with the lack of any consistent correlation between either the timing or magnitude of migration peaks of these two cell types, suggests that different mechanisms govern the egress of LC and γδ+ DC from the skin. It is concluded that the depression of normal immune function in the skin after exposure to erythemal doses of UV‐B radiation is associated with changes in the migration patterns of epidermal dendritic cells to local lymph nodes.

Bibliography

Dandie, G. W., Clydesdale, G. J., Radcliff, F. J., & Muller, H. K. (2001). Migration of Langerhans cells and Î³Î´+ dendritic cells from UVâBâirradiated sheep skin. Immunology & Cell Biology, 79(1), 41â48. Portico.

Authors 4

Geoffrey W Dandie (first)
Gavin J Clydesdale (additional)
Fiona J Radcliff (additional)
H Konrad Muller (additional)

References 34 Referenced 17

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Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 7:42 p.m.)
Deposited	1 year, 11 months ago (Sept. 29, 2023, 9:04 a.m.)
Indexed	1 year, 6 months ago (Feb. 23, 2024, 10:10 a.m.)
Issued	24 years, 6 months ago (Feb. 1, 2001)
Published	24 years, 6 months ago (Feb. 1, 2001)
Published Online	24 years, 6 months ago (Feb. 1, 2001)
Published Print	24 years, 6 months ago (Feb. 1, 2001)

Funders 2

National Health and Medical Research Council of Australia
Cancer Council of Tasmania

BibTeX

@article{Dandie_2001, title={Migration of Langerhans cells and γδ+ dendritic cells from UV‐B‐irradiated sheep skin}, volume={79}, ISSN={1440-1711}, url={http://dx.doi.org/10.1046/j.1440-1711.2001.00975.x}, DOI={10.1046/j.1440-1711.2001.00975.x}, number={1}, journal={Immunology & Cell Biology}, publisher={Wiley}, author={Dandie, Geoffrey W and Clydesdale, Gavin J and Radcliff, Fiona J and Muller, H Konrad}, year={2001}, month=feb, pages={41–48} }

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