DOI: 10.1046/j.1432-1327.2000.01595.x. Glutathione, oxidative stress and neurodegeneration

Glutathione, oxidative stress and neurodegeneration

10.1046/j.1432-1327.2000.01595.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

There is significant evidence that the pathogenesis of several neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic lateral sclerosis, may involve the generation of reactive oxygen species and mitochondrial dysfunction. Here, we review the evidence for a disturbance of glutathione homeostasis that may either lead to or result from oxidative stress in neurodegenerative disorders. Glutathione is an important intracellular antioxidant that protects against a variety of different antioxidant species. An important role for glutathione was proposed for the pathogenesis of Parkinson's disease, because a decrease in total glutathione concentrations in the substantia nigra has been observed in preclinical stages, at a time at which other biochemical changes are not yet detectable. Because glutathione does not cross the blood–brain barrier other treatment options to increase brain concentrations of glutathione including glutathione analogs, mimetics or precursors are discussed.

Bibliography

Schulz, J. B., Lindenau, J., Seyfried, J., & Dichgans, J. (2000). Glutathione, oxidative stress and neurodegeneration. European Journal of Biochemistry, 267(16), 4904â4911. Portico.

Authors 4

Jörg B. Schulz (first)
Jörg Lindenau (additional)
Jan Seyfried (additional)
Johannes Dichgans (additional)

References 76 Referenced 950

10.1046/j.1432-1327.2000.01597.x
10.1111/j.1749-6632.2000.tb06182.x
10.1126/science.8235659
10.4049/jimmunol.154.7.3194 / J. Immunol. / Thiol‐mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis by Sato N. (1995)
10.4049/jimmunol.158.10.4612 / J. Immunol. / Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis by Macho A. (1997)
{'key': 'e_1_2_11_7_2', 'first-page': '47', 'article-title': 'A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes', 'volume': '68', 'author': 'Beaver J.P.', 'year': '1995', 'journal-title': 'Eur. J. Cell Biol.'} / Eur. J. Cell Biol. / A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes by Beaver J.P. (1995)
10.1074/jbc.271.26.15420
10.1042/bj3250315
10.1016/S0896-6273(00)80953-8
10.1016/s0006-8993(99)01228-7
10.1016/s0304-3940(99)00107-x
10.1002/ana.410340416
10.1126/science.273.5271.59
10.1212/WNL.52.7.1492
10.1002/ana.410380304
10.1073/pnas.86.4.1398
10.1016/0304-3940(82)90390-1
10.1016/0304-3940(86)90320-4
10.1212/WNL.38.6.943
10.1016/0304-3940(87)90061-9
10.1111/j.1471-4159.1989.tb09150.x
10.1002/ana.410360306
10.1016/0304-3940(92)90355-B
10.1002/ana.410350107
10.1073/pnas.88.5.1913
10.1007/BF01291884
10.1016/0041-008X(91)90204-R
10.1111/j.1460-9568.1994.tb00990.x
10.1046/j.1471-4159.1999.0732469.x
10.1046/j.1471-4159.1999.0730112.x
10.1016/0022-510X(90)90225-C
10.1111/j.1471-4159.1993.tb13610.x
10.1007/BF01271295
10.1111/j.1471-4159.1989.tb02550.x
10.1007/BF01271243
10.1097/00001756-199603220-00018
10.1523/JNEUROSCI.20-01-00001.2000 / J. Neurosci. / Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3‐nitropropionic acid, and 1‐methyl‐4‐phenyl‐1,2,5,6‐tetrahydropyridine by Klivenyi P. (2000)
10.1002/(sici)1098-1136(199810)24:2<252::aid-glia10>3.0.co;2-z
10.1046/j.1471-4159.1998.71052112.x
10.1021/jm00034a006
10.1021/tx960008f
10.1046/j.1471-4159.1997.69041530.x
10.1016/s0140-6736(98)03453-9
10.1097/00019052-199408000-00010
10.1016/s0197-0186(99)00156-4
10.1007/BF00995149
10.1056/NEJM199704243361704
10.1212/WNL.45.8.1594
10.1006/exnr.1997.6750
10.1002/ana.410210403
10.1385/JMN:11:2:151
10.1212/WNL.51.6.1562
10.1046/j.1471-4159.1997.69052064.x
10.1016/0092-8674(95)90346-1
10.1002/ana.410420416
10.1073/pnas.94.14.7606
10.1002/1531-8249(199907)46:1<129::AID-ANA21>3.0.CO;2-Y
10.1002/ana.410440518
10.1002/ana.410440419
10.1016/S0165-0173(97)00045-3
10.1016/0304-3940(93)90236-E
10.1016/s0022-510x(97)00109-3
{'key': 'e_1_2_11_64_2', 'first-page': '325', 'article-title': 'Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation', 'volume': '17', 'author': 'Apostolski S.', 'year': '1998', 'journal-title': 'J. Environ. Pathol. Toxicol. Oncol.'} / J. Environ. Pathol. Toxicol. Oncol. / Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation by Apostolski S. (1998)
10.1006/neur.1996.0008
10.1006/neur.1995.0047
10.1002/ana.410390204
10.1002/(sici)1097-4547(19960801)45:3<276::aid-jnr9>3.0.co;2-a
10.1046/j.1460-9568.2000.00229.x
{'key': 'e_1_2_11_70_2', 'first-page': '221', 'article-title': 'Protective actions of YM737, a new glutathione analog, against cerebral ischemia in rats', 'volume': '81', 'author': 'Yamamoto M.', 'year': '1993', 'journal-title': 'Res. Commun. Chem. Pathol. Pharmacol.'} / Res. Commun. Chem. Pathol. Pharmacol. / Protective actions of YM737, a new glutathione analog, against cerebral ischemia in rats by Yamamoto M. (1993)
10.1523/JNEUROSCI.16-23-07574.1996
{'key': 'e_1_2_11_72_2', 'first-page': '851', 'article-title': 'l‐2‐oxothiazolidine‐4‐carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid‐deficient diet', 'volume': '125', 'author': 'Jain A.', 'year': '1995', 'journal-title': 'J. Nutr.'} / J. Nutr. / l‐2‐oxothiazolidine‐4‐carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid‐deficient diet by Jain A. (1995)
10.1016/s0304-3940(98)00894-5
10.1126/science.2185543
10.1016/0006-2952(92)90121-X
10.1523/JNEUROSCI.19-02-00562.1999
10.1016/S0140-6736(94)92347-7

Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 7:52 a.m.)
Deposited	1 year, 10 months ago (Oct. 15, 2023, 10:16 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 9:26 a.m.)
Issued	25 years, 1 month ago (Aug. 1, 2000)
Published	25 years, 1 month ago (Aug. 1, 2000)
Published Online	23 years, 8 months ago (Dec. 25, 2001)
Published Print	25 years, 1 month ago (Aug. 1, 2000)

Funders 0

None

BibTeX

@article{Schulz_2000, title={Glutathione, oxidative stress and neurodegeneration}, volume={267}, ISSN={1432-1033}, url={http://dx.doi.org/10.1046/j.1432-1327.2000.01595.x}, DOI={10.1046/j.1432-1327.2000.01595.x}, number={16}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={Schulz, Jörg B. and Lindenau, Jörg and Seyfried, Jan and Dichgans, Johannes}, year={2000}, month=aug, pages={4904–4911} }

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