DOI: 10.1046/j.1432-1033.2003.03655.x. Mechanism of protection of peroxidase activity by oscillatory dynamics

Mechanism of protection of peroxidase activity by oscillatory dynamics

10.1046/j.1432-1033.2003.03655.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

The peroxidase–oxidase reaction is known to involve reactive oxygen species as intermediates. These intermediates inactivate many types of biomolecules, including peroxidase itself. Previously, we have shown that oscillatory dynamics in the peroxidase–oxidase reaction seem to protect the enzyme from inactivation. It was suggested that this is due to a lower average concentration of reactive oxygen species in the oscillatory state compared to the steady state. Here, we studied the peroxidase–oxidase reaction with either 4‐hydroxybenzoic acid or melatonin as cofactors. We show that the protective effect of oscillatory dynamics is present in both cases. We also found that the enzyme degradation depends on the concentration of the cofactor and on the pH of the reaction mixture. We simulated the oscillatory behaviour, including the oscillation/steady state bistability observed experimentally, using a detailed reaction scheme. The computational results confirm the hypothesis that protection is due to lower average concentrations of superoxide radical during oscillations. They also show that the shape of the oscillations changes with increasing cofactor concentration resulting in a further decrease in the average concentration of radicals. We therefore hypothesize that the protective effect of oscillatory dynamics is a general effect in this system.

Bibliography

Olsen, L. F., Hauser, M. J. B., & Kummer, U. (2003). Mechanism of protection of peroxidase activity by oscillatory dynamics. European Journal of Biochemistry, 270(13), 2796â2804. Portico.

Authors 3

Lars F. Olsen (first)
Marcus J. B. Hauser (additional)
Ursula Kummer (additional)

References 46 Referenced 29

10.1017/CBO9780511608193
10.1016/0006-3002(57)90141-5
10.1016/0003-9861(68)90649-8
10.1073/pnas.71.5.2118
10.1038/319600a0
10.1103/PhysRevLett.84.2754
10.1006/cimm.1999.1481
10.1126/science.2294601
10.1038/27094
10.1016/S0167-4889(99)00148-2
10.1016/B978-0-12-287960-9.50039-3
10.1039/b103076k
10.1021/cr960081a
10.1038/222794a0
10.1016/0005-2744(78)90035-9
10.1074/jbc.272.9.5469
10.1042/bj3540107
{'key': 'e_1_2_7_19_2', 'first-page': '5', 'article-title': 'Phagocyte‐generated oxygen metabolites and cellular injury', 'volume': '47', 'author': 'Weiss S.J.', 'year': '1982', 'journal-title': 'Laboratory Invest.'} / Laboratory Invest. / Phagocyte‐generated oxygen metabolites and cellular injury by Weiss S.J. (1982)
{'key': 'e_1_2_7_20_2', 'first-page': '1', 'volume-title': 'Physiology of Oxygen Radicals', 'author': 'Grisham M.B.', 'year': '1986'} / Physiology of Oxygen Radicals by Grisham M.B. (1986)
10.1016/S0891-5849(00)00320-8
10.1074/jbc.273.8.4516
10.1039/ft9969202857
10.1021/jp993284m
10.1039/a910319h
10.1007/BFb0104230 / Transport and Structure – Their Competitive Role in Biophysics and Chemistry by Hauser M.J.B. (1999)
10.1038/2171047b0
10.1021/ja00174a030
10.1021/bi972424k
10.1016/0301-4622(95)00102-6
10.1016/0300-9084(96)81330-7
10.1006/bbrc.2001.5047
10.1016/0891-5849(96)00046-9
10.1016/S0891-5849(96)00614-4
10.1006/bbrc.1998.9426
10.1046/j.1432-1327.2000.01554.x
10.1021/j100023a001
10.1016/S0003-9861(02)00689-6
10.1006/abbi.1996.0122
10.1016/S0005-2728(00)00252-8
10.1063/1.555739
10.1046/j.1432-1327.1999.00199.x
Klebanoff S.J.(1991)Myeloperoxidase: Occurrence and biological function. InPeroxidases in Chemistry and Biology(Everse J. Everse K.E.&Grisham M.B. eds) Vol.1 pp.1–35.CRC Press Boston.
10.1042/bj2800727
10.1083/jcb.56.2.379
10.1016/S0006-3495(03)74833-4
10.1042/bj3130017

Dates

Type	When
Created	22 years, 2 months ago (June 19, 2003, 11:51 a.m.)
Deposited	1 year, 9 months ago (Oct. 31, 2023, 3:19 p.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 3:18 a.m.)
Issued	22 years, 2 months ago (June 12, 2003)
Published	22 years, 2 months ago (June 12, 2003)
Published Online	22 years, 2 months ago (June 12, 2003)
Published Print	22 years, 1 month ago (July 1, 2003)

Funders 0

None

BibTeX

@article{Olsen_2003, title={Mechanism of protection of peroxidase activity by oscillatory dynamics}, volume={270}, ISSN={1432-1033}, url={http://dx.doi.org/10.1046/j.1432-1033.2003.03655.x}, DOI={10.1046/j.1432-1033.2003.03655.x}, number={13}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={Olsen, Lars F. and Hauser, Marcus J. B. and Kummer, Ursula}, year={2003}, month=jun, pages={2796–2804} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        11,
        23
      ]
    ],
    "date-time": "2023-11-23T08:18:52Z",
    "timestamp": 1700727532374
  },
  "reference-count": 46,
  "publisher": "Wiley",
  "issue": "13",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            6,
            12
          ]
        ],
        "date-time": "2003-06-12T00:00:00Z",
        "timestamp": 1055376000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        7
      ]
    ]
  },
  "abstract": "<jats:p>The peroxidase\u2013oxidase reaction is known to involve reactive oxygen species as intermediates. These intermediates inactivate many types of biomolecules, including peroxidase itself. Previously, we have shown that oscillatory dynamics in the peroxidase\u2013oxidase reaction seem to protect the enzyme from inactivation. It was suggested that this is due to a lower average concentration of reactive oxygen species in the oscillatory state compared to the steady state. Here, we studied the peroxidase\u2013oxidase reaction with either 4\u2010hydroxybenzoic acid or melatonin as cofactors. We show that the protective effect of oscillatory dynamics is present in both cases. We also found that the enzyme degradation depends on the concentration of the cofactor and on the pH of the reaction mixture. We simulated the oscillatory behaviour, including the oscillation/steady state bistability observed experimentally, using a detailed reaction scheme. The computational results confirm the hypothesis that protection is due to lower average concentrations of superoxide radical during oscillations. They also show that the shape of the oscillations changes with increasing cofactor concentration resulting in a further decrease in the average concentration of radicals. We therefore hypothesize that the protective effect of oscillatory dynamics is a general effect in this system.</jats:p>",
  "DOI": "10.1046/j.1432-1033.2003.03655.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        6,
        19
      ]
    ],
    "date-time": "2003-06-19T15:51:54Z",
    "timestamp": 1056037914000
  },
  "page": "2796-2804",
  "source": "Crossref",
  "is-referenced-by-count": 29,
  "title": "Mechanism of protection of peroxidase activity by oscillatory dynamics",
  "prefix": "10.1111",
  "volume": "270",
  "author": [
    {
      "given": "Lars F.",
      "family": "Olsen",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Marcus J. B.",
      "family": "Hauser",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ursula",
      "family": "Kummer",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2003,
        6,
        12
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_7_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1017/CBO9780511608193"
    },
    {
      "key": "e_1_2_7_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-3002(57)90141-5"
    },
    {
      "key": "e_1_2_7_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-9861(68)90649-8"
    },
    {
      "key": "e_1_2_7_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.71.5.2118"
    },
    {
      "key": "e_1_2_7_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/319600a0"
    },
    {
      "key": "e_1_2_7_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.84.2754"
    },
    {
      "key": "e_1_2_7_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/cimm.1999.1481"
    },
    {
      "key": "e_1_2_7_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2294601"
    },
    {
      "key": "e_1_2_7_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/27094"
    },
    {
      "key": "e_1_2_7_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0167-4889(99)00148-2"
    },
    {
      "key": "e_1_2_7_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/B978-0-12-287960-9.50039-3"
    },
    {
      "key": "e_1_2_7_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/b103076k"
    },
    {
      "key": "e_1_2_7_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cr960081a"
    },
    {
      "key": "e_1_2_7_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/222794a0"
    },
    {
      "key": "e_1_2_7_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0005-2744(78)90035-9"
    },
    {
      "key": "e_1_2_7_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.9.5469"
    },
    {
      "key": "e_1_2_7_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3540107"
    },
    {
      "key": "e_1_2_7_19_2",
      "first-page": "5",
      "article-title": "Phagocyte\u2010generated oxygen metabolites and cellular injury",
      "volume": "47",
      "author": "Weiss S.J.",
      "year": "1982",
      "journal-title": "Laboratory Invest."
    },
    {
      "key": "e_1_2_7_20_2",
      "first-page": "1",
      "volume-title": "Physiology of Oxygen Radicals",
      "author": "Grisham M.B.",
      "year": "1986"
    },
    {
      "key": "e_1_2_7_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0891-5849(00)00320-8"
    },
    {
      "key": "e_1_2_7_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.8.4516"
    },
    {
      "key": "e_1_2_7_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/ft9969202857"
    },
    {
      "key": "e_1_2_7_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp993284m"
    },
    {
      "key": "e_1_2_7_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/a910319h"
    },
    {
      "key": "e_1_2_7_26_2",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.1007/BFb0104230",
      "volume-title": "Transport and Structure \u2013 Their Competitive Role in Biophysics and Chemistry",
      "author": "Hauser M.J.B.",
      "year": "1999"
    },
    {
      "key": "e_1_2_7_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/2171047b0"
    },
    {
      "key": "e_1_2_7_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00174a030"
    },
    {
      "key": "e_1_2_7_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi972424k"
    },
    {
      "key": "e_1_2_7_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0301-4622(95)00102-6"
    },
    {
      "key": "e_1_2_7_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0300-9084(96)81330-7"
    },
    {
      "key": "e_1_2_7_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.2001.5047"
    },
    {
      "key": "e_1_2_7_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0891-5849(96)00046-9"
    },
    {
      "key": "e_1_2_7_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0891-5849(96)00614-4"
    },
    {
      "key": "e_1_2_7_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1998.9426"
    },
    {
      "key": "e_1_2_7_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1432-1327.2000.01554.x"
    },
    {
      "key": "e_1_2_7_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100023a001"
    },
    {
      "key": "e_1_2_7_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0003-9861(02)00689-6"
    },
    {
      "key": "e_1_2_7_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/abbi.1996.0122"
    },
    {
      "key": "e_1_2_7_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0005-2728(00)00252-8"
    },
    {
      "key": "e_1_2_7_41_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.555739"
    },
    {
      "key": "e_1_2_7_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1432-1327.1999.00199.x"
    },
    {
      "key": "e_1_2_7_43_2",
      "unstructured": "Klebanoff S.J.(1991)Myeloperoxidase: Occurrence and biological function. InPeroxidases in Chemistry and Biology(Everse J. Everse K.E.&Grisham M.B. eds) Vol.1 pp.1\u201335.CRC Press Boston."
    },
    {
      "key": "e_1_2_7_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj2800727"
    },
    {
      "key": "e_1_2_7_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.56.2.379"
    },
    {
      "key": "e_1_2_7_46_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(03)74833-4"
    },
    {
      "key": "e_1_2_7_47_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3130017"
    }
  ],
  "container-title": "European Journal of Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1432-1033.2003.03655.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1046/j.1432-1033.2003.03655.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        31
      ]
    ],
    "date-time": "2023-10-31T19:19:53Z",
    "timestamp": 1698779993000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1046/j.1432-1033.2003.03655.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        6,
        12
      ]
    ]
  },
  "references-count": 46,
  "journal-issue": {
    "issue": "13",
    "published-print": {
      "date-parts": [
        [
          2003,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1046/j.1432-1033.2003.03655.x"
  ],
  "URL": "http://dx.doi.org/10.1046/j.1432-1033.2003.03655.x",
  "relation": {},
  "ISSN": [
    "0014-2956",
    "1432-1033"
  ],
  "subject": [],
  "container-title-short": "European Journal of Biochemistry",
  "published": {
    "date-parts": [
      [
        2003,
        6,
        12
      ]
    ]
  }
}