DOI: 10.1046/j.1365-2958.2002.03126.x. Genome sequence of <i>Streptococcus agalactiae</i>, a pathogen causing invasive neonatal disease

Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease

10.1046/j.1365-2958.2002.03126.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

Summary Streptococcus agalactiae is a commensal bacterium colonizing the intestinal tract of a significant proportion of the human population. However, it is also a pathogen which is the leading cause of invasive infections in neonates and causes septicaemia, meningitis and pneumonia. We sequenced the genome of the serogroup III strain NEM316, responsible for a fatal case of septicaemia. The genome is 2 211 485 base pairs long and contains 2118 protein coding genes. Fifty‐five per cent of the predicted genes have an ortholog in the Streptococcus pyogenes genome, representing a conserved backbone between these two streptococci. Among the genes in S. agalactiae that lack an ortholog in S. pyogenes , 50% are clustered within 14 islands. These islands contain known and putative virulence genes, mostly encoding surface proteins as well as a number of genes related to mobile elements. Some of these islands could therefore be considered as pathogenicity islands. Compared with other pathogenic streptococci, S. agalactiae shows the unique feature that pathogenicity islands may have an important role in virulence acquisition and in genetic diversity.

Bibliography

Glaser, P., Rusniok, C., Buchrieser, C., Chevalier, F., Frangeul, L., Msadek, T., Zouine, M., CouvÃ©, E., Lalioui, L., Poyart, C., TrieuâCuot, P., & Kunst, F. (2002). Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease. Molecular Microbiology, 45(6), 1499â1513. Portico.

Authors 12

Philippe Glaser (first)
Christophe Rusniok (additional)
Carmen Buchrieser (additional)
Fabien Chevalier (additional)
Lionel Frangeul (additional)
Tarek Msadek (additional)
Mohamed Zouine (additional)
Elisabeth Couvé (additional)
Lila Lalioui (additional)
Claire Poyart (additional)
Patrick Trieu‐Cuot (additional)
Frank Kunst (additional)

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Dates

Type	When
Created	22 years, 5 months ago (March 12, 2003, 6:45 a.m.)
Deposited	1 year, 10 months ago (Oct. 17, 2023, 6:43 p.m.)
Indexed	2 months ago (July 5, 2025, 8:33 p.m.)
Issued	23 years ago (Sept. 1, 2002)
Published	23 years ago (Sept. 1, 2002)
Published Online	22 years, 11 months ago (Sept. 27, 2002)
Published Print	23 years ago (Sept. 1, 2002)

Funders 0

None

BibTeX

@article{Glaser_2002, title={Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease}, volume={45}, ISSN={1365-2958}, url={http://dx.doi.org/10.1046/j.1365-2958.2002.03126.x}, DOI={10.1046/j.1365-2958.2002.03126.x}, number={6}, journal={Molecular Microbiology}, publisher={Wiley}, author={Glaser, Philippe and Rusniok, Christophe and Buchrieser, Carmen and Chevalier, Fabien and Frangeul, Lionel and Msadek, Tarek and Zouine, Mohamed and Couvé, Elisabeth and Lalioui, Lila and Poyart, Claire and Trieu‐Cuot, Patrick and Kunst, Frank}, year={2002}, month=sep, pages={1499–1513} }

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