DOI: 10.1046/j.1365-2958.2000.01873.x. Phase variation of the gonococcal siderophore receptor FetA

Phase variation of the gonococcal siderophore receptor FetA

10.1046/j.1365-2958.2000.01873.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

FetA, the recently characterized gonococcal ferric enterobactin receptor, exhibited extremely rapid phase variation between high‐ and low‐expression levels. The frequency of phase variation was ≈ 1.3% in both directions in gonococcal strain FA1090. FetA expression in the ‘high phase’ was significantly greater than the level of expression in the ‘low phase’. Expression levels correlated with the number of cytosine residues in a string of cytosines located close to the transcriptional start site for fetA between the putative −10 and −35 consensus sequences. Antibody production against FetA commonly occurs in infected patients, and we therefore hypothesize that phase variation reflects a balance between the advantages of being able to use a ferric siderophore as an iron source and evasion of the host immune response.

Bibliography

Carson, S. D. B., Stone, B., Beucher, M., Fu, J., & Sparling, P. F. (2000). Phase variation of the gonococcal siderophore receptor FetA. Molecular Microbiology, 36(3), 585â593. Portico.

Authors 5

Susan D. Biegel Carson (first)
Barbara Stone (additional)
Margaret Beucher (additional)
Jennifer Fu (additional)
P. Frederick Sparling (additional)

References 34 Referenced 41

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{'key': 'e_1_2_6_12_2', 'first-page': '509', 'article-title': 'Use of a non‐selective transformation technique to construct a multiply restriction/modification‐deficient mutant of Neisseria gonorrhoeae', 'volume': '251', 'author': 'Gunn J.S.', 'year': '1996', 'journal-title': 'Mol Gen Genet'} / Mol Gen Genet / Use of a non‐selective transformation technique to construct a multiply restriction/modification‐deficient mutant of Neisseria gonorrhoeae by Gunn J.S. (1996)
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Dates

Type	When
Created	22 years, 5 months ago (March 12, 2003, 6:30 a.m.)
Deposited	1 year, 10 months ago (Oct. 29, 2023, 3:02 a.m.)
Indexed	4 months, 4 weeks ago (April 9, 2025, 2:02 a.m.)
Issued	25 years, 4 months ago (May 1, 2000)
Published	25 years, 4 months ago (May 1, 2000)
Published Online	23 years, 7 months ago (Jan. 18, 2002)
Published Print	25 years, 4 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Carson_2000, title={Phase variation of the gonococcal siderophore receptor FetA}, volume={36}, ISSN={1365-2958}, url={http://dx.doi.org/10.1046/j.1365-2958.2000.01873.x}, DOI={10.1046/j.1365-2958.2000.01873.x}, number={3}, journal={Molecular Microbiology}, publisher={Wiley}, author={Carson, Susan D. Biegel and Stone, Barbara and Beucher, Margaret and Fu, Jennifer and Sparling, P. Frederick}, year={2000}, month=may, pages={585–593} }

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