DOI: 10.1046/j.1365-2958.1998.00908.x. The <i>Salmonella typhimurium</i> InvH protein is an outer membrane lipoprotein required for the proper localization of InvG

The Salmonella typhimurium InvH protein is an outer membrane lipoprotein required for the proper localization of InvG

10.1046/j.1365-2958.1998.00908.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

The secretion of pathogenicity factors by Salmonella typhimurium is mediated by a type III secretion system that includes an outer membrane protein of the secretin family. Related secretins are also required for f1 phage assembly and type II secretion. When the C‐terminal 43 amino acids of the S. typhimurium secretin InvG are added to f1 pIV, the chimeric f1 pIV‐′InvG43 protein becomes dependent on the co‐expression of another gene, invH, for function in phage assembly. [3H]‐palmitic acid labelling, globomycin sensitivity and density gradient flotation were used to demonstrate that InvH is an outer membrane lipoprotein that is processed by signal peptidase II. A complex between chimeric f1 pIV‐′InvG43 and InvH was demonstrated in vivo. InvH was shown to be required for the proper localization of InvG in the outer membrane and for the secretion of the virulence factor SipC. These results suggest that InvH and InvG are part of the functional outer membrane translocation complex in type III secretion systems.

Bibliography

Daefler, S., & Russel, M. (1998). The Salmonella typhimurium InvH protein is an outer membrane lipoprotein required for the proper localization of InvG. Molecular Microbiology, 28(6), 1367â1380. Portico.

Authors 2

Simon Daefler (first)
Marjorie Russel (additional)

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Dates

Type	When
Created	22 years, 5 months ago (March 12, 2003, 6:18 a.m.)
Deposited	1 year, 9 months ago (Oct. 28, 2023, 5:25 a.m.)
Indexed	1 year, 3 months ago (May 6, 2024, 12:34 p.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Online	22 years, 9 months ago (Nov. 18, 2002)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Daefler_1998, title={The Salmonella typhimurium InvH protein is an outer membrane lipoprotein required for the proper localization of InvG}, volume={28}, ISSN={1365-2958}, url={http://dx.doi.org/10.1046/j.1365-2958.1998.00908.x}, DOI={10.1046/j.1365-2958.1998.00908.x}, number={6}, journal={Molecular Microbiology}, publisher={Wiley}, author={Daefler, Simon and Russel, Marjorie}, year={1998}, month=jun, pages={1367–1380} }

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