DOI: 10.1046/j.1365-2249.2002.01968.x. Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens of<i>Aspergillus fumigatus</i>

Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens ofAspergillus fumigatus

10.1046/j.1365-2249.2002.01968.x

Crossref journal-article

Oxford University Press (OUP)

Clinical and Experimental Immunology (286)

Abstract

SummaryC57BL/6 mice were sensitized to Aspergillus fumigatus 1-week culture filtrate, which is rich in the non-glycosylated allergen Asp f1, a major allergen in allergic bronchopulmonary aspergillosis (ABPA). A comparison of the effect of treatment of allergen challenged mice by intranasal administration of a 60-kDa truncated recombinant form of human SP-D (rfhSP-D) or recombinant full length SP-A (rhSP-A) was undertaken. Treatment with rfhSP-D produced significant reduction in IgE, IgG1 and peripheral blood eosinophilia and treatment with rfhSP-D, but not rhSP-A resulted in a significant reduction in airway hyperresponsiveness as measured by whole body plethysmography. Lung histology revealed less peribronchial lymphocytic infiltration in mice treated with rfhSP-D. Intracellular cytokine staining of spleen homogenates showed increases in IL-12 and IFN-γ and decrease in IL-4. The level of endogenous mouse SP-D was elevated sixfold in the lungs of sensitized mice and was not affected by treatment with rfhSP-D. Taken with our previous studies, with a BALB/c mouse model of ABPA using a 3-week A. fumigatus culture filtrate, the present results show that rfhSP-D can suppress the development of allergic symptoms in sensitized mice independent of genetic background and using a different preparation of A. fumigatus allergens.

Bibliography

STRONG, P., REID, K. B. M., & CLARK, H. (2002). Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens ofAspergillus fumigatus. Clinical and Experimental Immunology, 130(1), 19â24.

Authors 3

P STRONG (first)
K B M REID (additional)
H CLARK (additional)

References 29 Referenced 68

10.1164/ajrccm.151.6.7767565 / Am J Respir Crit Care Med / Review of fungus-induced asthmatic reactions by Kauffman (1995)
{'key': '2022011221521333300_b2', 'first-page': '27', 'article-title': 'Aspergillosis and lung defenses', 'volume': '6', 'author': 'Elstad', 'year': '1991', 'journal-title': 'Semin Respir Infect'} / Semin Respir Infect / Aspergillosis and lung defenses by Elstad (1991)
{'key': '2022011221521333300_b3', 'first-page': '48', 'article-title': 'Beware of the fungus', 'volume': '97', 'author': 'Varkey', 'year': '1998', 'journal-title': 'Wisconsin Medical Journal'} / Wisconsin Medical Journal / Beware of the fungus by Varkey (1998)
10.1016/S0952-7915(99)80006-5 / Curr Opin Immunol / Lung surfactant proteins involved in innate immunity by Eggleton (1999)
10.1165/ajrcmb.19.2.140 / Am J Respir Cell Mol Biol / Collectins and pulmonary host defense by Crouch (1998)
10.1164/ajrccm.158.2.9709111 / Am J Respir Crit Care Med / Inhibitory effect of pulmonary surfactant proteins A and D on allergen-induced lymphocyte proliferation and histamine release in children with asthma by Wang (1998)
10.1046/j.1365-2249.1996.d01-838.x / Clin Exp Immunol / Interaction of human lung surfactant proteins A and D with mite (Dermatophagoides pteronyssinus) allergens by Wang (1996)
10.1111/j.1365-2249.1997.tb08323.x / Clin Exp Immunol / Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen-induced histamine release from human basophils by Madan (1997)
10.1183/09031936.00.16583100 / Eur Respir J / Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma by Cheng (2000)
10.1172/JCI10124 / J Clin Invest / Surfactant proteins A and D protect mice against pulmonary hypersensitivity induced by Aspergillus fumigatus antigens and allergens by Madan (2001)
10.1016/S0925-4439(98)00073-8 / Biochim Biophys Acta / Structure, biologic properties, and expression of surfactant protein D (SP-D) by Crouch (1998)
10.1016/S0925-4439(98)00074-X / Biochim Biophys Acta / Interactions of surfactant protein D with pathogens, allergens and phagocytes by Reid (1998)
10.4049/jimmunol.149.10.3354 / J Immunol / Selective expression of a major allergen and cytotoxin, Asp fI, in Aspergillus fumigatus. Implications for the immunopathogenesis of Aspergillus-related diseases by Arruda (1992)
10.1016/0022-2836(88)90448-2 / J Mol Biol / Macromolecular organization of natural and recombinant lung surfactant protein SP 28–36. Structural homology with the complement factor C1q by Voss (1988)
10.4049/jimmunol.162.10.6284 / J Immunol / Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides by Sur (1999)
10.1164/ajrccm.156.3.9606031 / Am J Respir Crit Care Med / Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography by Hamelmann (1997)
{'key': '2022011221521333300_b17', 'first-page': '805', 'article-title': 'Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive', 'volume': '41', 'author': 'Hazlett', 'year': '2000', 'journal-title': 'Invest Ophthalmol Vis Sci'} / Invest Ophthalmol Vis Sci / Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive by Hazlett (2000)
10.1002/(SICI)1521-4141(199804)28:04<1155::AID-IMMU1155>3.0.CO;2-6 / Eur J Immunol / Differential IgE recognition of recombinant Aspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis or Aspergillus allergy by Hemmann (1998)
10.1016/0091-6749(91)90102-T / J Allergy Clin Immunol / Variability in parameters of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis by Hutcheson (1991)
10.1016/S0140-6736(00)03497-8 / Lancet / Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response by Bryan (2000)
10.1084/jem.182.5.1527 / J Exp Med / Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice by Gavett (1995)
10.1073/pnas.90.8.3725 / Proc Natl Acad Sci USA / Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist by Tripp (1993)
10.1073/pnas.85.18.6880 / Proc Natl Acad Sci USA / IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2 by Pene (1988)
10.1111/j.1600-065X.1995.tb00093.x / Immunol Rev / Immune responses of IL-4, IL-5, IL-6 deficient mice by Kopf (1995)
10.1146/annurev.iy.12.040194.001455 / Annu Rev Immunol / Immunological aspects of allergic asthma by Bochner (1994)
10.1056/NEJM199201303260504 / N Engl J Med / Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma by Robinson (1992)
10.1016/0091-6749(91)90251-I / J Allergy Clin Immunol / Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity by Walker (1991)
10.1165/ajrcmb.26.2.4600 / Am J Respir Cell Mol Biol / The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells by Venkayya (2002)
10.1165/ajrcmb.25.1.4391 / Am J Respir Cell Mol Biol / Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice by Haczku (2001)

Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 5:33 a.m.)
Deposited	1 year, 7 months ago (Jan. 7, 2024, 3:23 a.m.)
Indexed	1 week, 2 days ago (Aug. 21, 2025, 1:06 p.m.)
Issued	22 years, 11 months ago (Sept. 19, 2002)
Published	22 years, 11 months ago (Sept. 19, 2002)
Published Online	22 years, 11 months ago (Sept. 19, 2002)
Published Print	22 years, 11 months ago (Sept. 19, 2002)

Funders 0

None

BibTeX

@article{STRONG_2002, title={Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens ofAspergillus fumigatus}, volume={130}, ISSN={1365-2249}, url={http://dx.doi.org/10.1046/j.1365-2249.2002.01968.x}, DOI={10.1046/j.1365-2249.2002.01968.x}, number={1}, journal={Clinical and Experimental Immunology}, publisher={Oxford University Press (OUP)}, author={STRONG, P and REID, K B M and CLARK, H}, year={2002}, month=sep, pages={19–24} }

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