DOI: 10.1046/j.1365-2249.2002.01837.x. Effect of CD14 promoter polymorphism and<i>H. pylori</i>infection and its clinical outcomes on circulating CD14

Effect of CD14 promoter polymorphism andH. pyloriinfection and its clinical outcomes on circulating CD14

10.1046/j.1365-2249.2002.01837.x

Crossref journal-article

Oxford University Press (OUP)

Clinical and Experimental Immunology (286)

Abstract

SUMMARYCD14 is a pattern recognition receptor on the membranes of monocytes and macrophages for several microbial products, of which lipopolysaccharide (LPS) is the best known. A shed form of CD14 is present in serum. As the CD14 gene promoter polymorphism –159C/T and some bacterial infections may affect the sCD14 levels, we compared the impact of both the CD14 promoter polymorphism and Helicobacter pylori infection on serum sCD14 levels in 201 dyspeptic patients (group 1) who had undergone gastroscopy, and 127 staff members (group 2) with no endoscopy. sCD14 was measured from the sera by a commercial enzyme immunoassay (EIA), and CD14 genotyping was carried out with PCR. Helicobacter pylori infection was detected by serology and/or culture or PCR. sCD14 levels were elevated in the subjects carrying the T allele (CT or TT genotype) in both groups when compared with subjects with the CC genotype. Overall, H. pylori-positive subjects tended to have higher sCD14 levels compared with H. pylori-negative subjects. In group 1 consisting of dyspeptic patients, those with gastric ulcer, gastric erosion or duodenal ulcer had significantly elevated levels of sCD14 compared with the patients with normal endoscopic findings or macroscopic gastritis. The recent use of NSAIDs was also associated with enhanced sCD14. Thus, we were able to show several factors, one genetic and the other environmental (H. pylori infection and mucosal lesion), to have an impact on sCD14.

Bibliography

KARHUKORPI, J., YAN, Y., NIEMELÃ, S., VALTONEN, J., KOISTINEN, P., JOENSUU, T., SAIKKU, P., & KARTTUNEN, R. (2002). Effect of CD14 promoter polymorphism andH. pyloriinfection and its clinical outcomes on circulating CD14. Clinical and Experimental Immunology, 128(2), 326â332.

Authors 8

J KARHUKORPI (first)
Y YAN (additional)
S NIEMELÄ (additional)
J VALTONEN (additional)
P KOISTINEN (additional)
T JOENSUU (additional)
P SAIKKU (additional)
R KARTTUNEN (additional)

References 44 Referenced 72

10.1016/S0952-7915(99)00047-3 / Curr Opin Immunol / CD14-dependent clearance of apoptotic cells: relevance to the immune system by Gregory (2000)
10.1016/S1471-4906(00)01811-1 / Trends Immunol / Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice by Kaisho (2001)
10.1128/IAI.66.11.5089-5098.1998 / Infect Immun / Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia by Liu (1998)
10.1074/jbc.M003192200 / J Biol Chem / Hepatocytes contribute to soluble CD14 production, and CD14 expression is differentially regulated in hepatocytes and monocytes by Pan (2000)
10.1165/ajrcmb.20.5.3494 / Am J Respir Cell Mol Biol / A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E by Baldini (1999)
10.1126/science.1698311 / Science / CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein by Wright (1990)
10.4049/jimmunol.151.3.1500 / J Immunol / Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide by Haziot (1993)
10.1128/iai.63.3.1020-1026.1995 / Infect Immun / Endotocin activates human vascular smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14 by Loppnow (1995)
10.1073/pnas.90.7.2744 / Proc Natl Acad Sci USA / Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipolysaccharide-binding protein and soluble CD14 by Pugin (1993)
10.1006/mpat.1997.0178 / Microb Pathogenesis / Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway by Frey (1998)
10.1182/blood.V92.8.2759 / Blood / Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells by Hu (1998)
10.1128/IAI.67.1.417-420.1999 / Infect Immun / Increased levels of soluble CD14 in sera of periodontitis patients by Hayashi (1999)
10.1086/314492 / J Infect Dis / Serum concentrations of lipopolysaccharide activity-modulating proteins during tuberculosis by Juffermans (1998)
10.1086/315357 / J Infect Dis / Soluble CD14 levels in the serum, synovial fluid, and cerebrospinal fluid of patients with various stages of Lyme disease by Lin (2000)
10.1046/j.1365-2249.2000.01120.x / Clin Exp Immunol / Increased levels of circulating soluble CD14 in Kawasaki disease by Takeshita (2000)
10.1093/infdis/171.3.639 / J Infect Dis / Increased circulating soluble CD14 is associated with high mortality in gram-negative septic shock by Landmann (1995)
10.1093/infdis/173.3.661 / J Infect Dis / Function of soluble CD14 in serum from patients with septic shock by Landmann (1996)
10.1136/bmj.316.7138.1130 / Br Med J / Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies by Danesh (1998)
10.1128/IAI.66.11.5357-5363.1998 / Infect Immun / Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes by Bliss (1998)
10.1128/jcm.33.1.28-32.1995 / J Clin Microbiol / Detection of Helicobacter pylori gene expression in human gastric mucosa by Peek (1995)
10.1128/JCM.37.7.2274-2279.1999 / J Clin Microbiol / Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries by Yamaoka (1999)
{'key': '2022011221431094400_b22', 'first-page': '1322', 'article-title': 'Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States', 'volume': '91', 'author': 'Miehlke', 'year': '1996', 'journal-title': 'Am J Gastroenterol'} / Am J Gastroenterol / Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States by Miehlke (1996)
10.1161/01.CIR.99.25.3218 / Circulation / C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction by Hubacek (1999)
{'key': '2022011221431094400_b24', 'first-page': '787', 'article-title': 'Helicobacter pylori lipopolysaccharide-mediated gastric and extragastric pathology', 'volume': '50', 'author': 'Moran', 'year': '1999', 'journal-title': 'J Physiol Pharmacol'} / J Physiol Pharmacol / Helicobacter pylori lipopolysaccharide-mediated gastric and extragastric pathology by Moran (1999)
10.3109/00365529709000195 / Scand J Gastroenterol / Induction of acute gastritis and epithelial apoptosis by Helicobacter pylori lipopolysaccharide by Piotrowski (1997)
10.4049/jimmunol.164.7.3480 / J Immunol / Human B cell function is regulated by interaction with soluble CD14: Opposite effects on IgG1 and IgE production by Arias (2000)
10.1002/(SICI)1521-4141(199901)29:01<265::AID-IMMU265>3.0.CO;2-G / Eur J Immunol / Soluble CD14 acts as a negative regulator of human T cell activation and function by Rey Nores (1999)
10.1161/01.STR.31.11.2661 / Stroke / Polymorphism in the promoter of lipopolysaccharide receptor CD14 and ischemic cerebrovascular disease by Ito (2000)
{'key': '2022011221431094400_b29', 'first-page': '110', 'volume-title': 'Pathogenesis and host response in Helicobacter pylori infections', 'author': 'Dixon', 'year': '1998'} / Pathogenesis and host response in Helicobacter pylori infections by Dixon (1998)
10.1128/iai.64.5.1762-1769.1996 / Infect Immun / Human monocyte CD14 is upregulated by lipopolysaccharide by Landmann (1996)
10.1084/jem.181.5.1743 / J Exp Med / Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein by Wurfel (1995)
10.1172/JCI119160 / J Clin Invest / Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids by Yu (1997)
10.1086/315611 / J Infect Dis / Infection and inflammation-induced proatherogenic changes of lipoproteins by Khovidhunkit (2000)
10.1016/s0021-9150(98)00194-4 / Atherosclerosis / Association of Helicobacter pylori infection with elevated serum lipids by Laurila (1999)
10.1136/hrt.75.6.573 / Heart / Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrationsarticle-title by Niemelä (1996)
10.1016/S0002-9149(00)00757-8 / Am J Cardiol / Circulating monocytes in patients with diabetes mellitus, arterial disease, and increased CD14 expression by Patino (2000)
10.1016/S0021-9150(99)00061-1 / Atherosclerosis / A more mature phenotype of blood mononuclear phagocytes is induced by fluvastatin treatment in hypercholesterolemic patients with coronary heart disease by Rothe (1999)
10.4049/jimmunol.166.2.826 / J Immunol / Soluble CD14 mediates efflux of phospholipids from cells by Sugiyama (2001)
10.1016/S0002-9149(00)01054-7 / Am J Cardiol / Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acute myocardial infarction in Japanese men by Shimada (2000)
10.1161/01.ATV.19.4.932 / Arterioscler Thromb Vasc Biol / A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with low expired myocardial infarction in patients with low atherosclerotic risk profile by Unkelbach (1999)
10.1016/0016-5085(88)90288-0 / Gastroenterology / Concordant occurrence of gastric and hypertensive diseases by Sonnenberg (1988)
10.1016/S0002-8703(99)70269-3 / Am Heart J / Role of infections in atherosclerosis by Valtonen (1999)
10.1164/ajrccm.163.4.2004164 / Am J Respir Crit Care Med / Association of a promoter polymorphism of the CD14 gene and atopy by Koppelman (2001)
10.1136/bmj.320.7232.412 / Br Med J / Exposure of foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study by Matricardi (2000)

Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 5:31 a.m.)
Deposited	2 years, 4 months ago (April 21, 2023, 10:49 p.m.)
Indexed	1 year ago (Aug. 15, 2024, 11:08 a.m.)
Issued	23 years, 3 months ago (May 1, 2002)
Published	23 years, 3 months ago (May 1, 2002)
Published Online	23 years, 3 months ago (May 2, 2002)
Published Print	23 years, 3 months ago (May 2, 2002)

Funders 0

None

BibTeX

@article{KARHUKORPI_2002, title={Effect of CD14 promoter polymorphism andH. pyloriinfection and its clinical outcomes on circulating CD14}, volume={128}, ISSN={1365-2249}, url={http://dx.doi.org/10.1046/j.1365-2249.2002.01837.x}, DOI={10.1046/j.1365-2249.2002.01837.x}, number={2}, journal={Clinical and Experimental Immunology}, publisher={Oxford University Press (OUP)}, author={KARHUKORPI, J and YAN, Y and NIEMELÄ, S and VALTONEN, J and KOISTINEN, P and JOENSUU, T and SAIKKU, P and KARTTUNEN, R}, year={2002}, month=may, pages={326–332} }

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      "journal-title": "Trends Immunol"
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      "volume": "275",
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      "journal-title": "J Biol Chem"
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      "volume": "20",
      "author": "Baldini",
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