DOI: 10.1046/j.1365-2222.2000.00982.x. Microflora‐associated characteristics in faeces from allergic and nonallergic infants

Microflora‐associated characteristics in faeces from allergic and nonallergic infants

10.1046/j.1365-2222.2000.00982.x

Crossref journal-article

Wiley

Clinical & Experimental Allergy (311)

Abstract

Background The prevalence of allergic diseases has increased particularly over the past 30–40 years. A reduced microbial stimulation during infancy may result in a development of a disturbed balance between Th1‐ and Th2‐like immunity. The gut flora is, quantitatively, the most important source for such stimulation.Objective The aim of the study was to compare the gut microbial flora in 25 allergic and 47 nonallergic 13‐month‐old infants (range 11–18), through analysing microflora‐associated biochemical markers in faeces.Methods Microflora associated characteristics (MACs) were assessed by determining the concentrations of eight different short chain fatty acids and the conversion of cholesterol to coprostanol by gas chromatography. Faecal tryptic activity was analysed spectrophotometrically.Results The allergic infants had lower levels of propionic, i‐butyric, butyric, i‐valeric and valeric acid. In contrast, they had higher levels of the rarely detected i‐caproic acid, which has been associated with the presence of Clostridium difficile. Furthermore, the allergic infants had higher relative distribution of acetic and i‐caproic acid. None of the other parameters differed between the groups.Conclusion The results demonstrate differences in the MACs between allergic and nonallergic infants, indicating differences in the composition of the gut flora that may disturb the development of a normal Th1‐/Th2‐balance in allergic children.

Bibliography

BÃ¶ttcher, M. F., Nordin, E. K., Sandin, A., Midtvedt, T., & BjÃ¶rkstÃ©n, B. (2000). Microfloraâassociated characteristics in faeces from allergic and nonallergic infants. Clinical & Experimental Allergy, 30(11), 1591â1596. Portico.

Authors 5

M. F. Böttcher (first)
E. K. Nordin (additional)
A. Sandin (additional)
T. Midtvedt (additional)
B. Björkstén (additional)

References 29 Referenced 190

10.1073/pnas.85.18.6880
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{'key': 'e_1_2_6_14_2', 'first-page': '295', 'article-title': 'Microflora‐associated characteristics (MACs) and germ‐free animal characteristics (GACs) in man and animals', 'volume': '15', 'author': 'Midtvedt T.', 'year': '1985', 'journal-title': 'Microecol Ther'} / Microecol Ther / Microflora‐associated characteristics (MACs) and germ‐free animal characteristics (GACs) in man and animals by Midtvedt T. (1985)
10.1016/0009-8981(77)90312-6
10.1080/00365521.1984.12005738
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10.1093/jac/10.4.263
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10.1016/S0091-6749(97)70093-9
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MidtvedtA‐C.The establishment and development of some metabolic activities associated with the intestinal microflora in healthy children. Stockholm:Karolinska Institute 1994.

Dates

Type	When
Created	22 years, 5 months ago (March 11, 2003, 4:41 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 1:35 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 1:14 a.m.)
Issued	24 years, 10 months ago (Nov. 1, 2000)
Published	24 years, 10 months ago (Nov. 1, 2000)
Published Online	17 years ago (Sept. 5, 2008)
Published Print	24 years, 10 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{B_ttcher_2000, title={Microflora‐associated characteristics in faeces from allergic and nonallergic infants}, volume={30}, ISSN={1365-2222}, url={http://dx.doi.org/10.1046/j.1365-2222.2000.00982.x}, DOI={10.1046/j.1365-2222.2000.00982.x}, number={11}, journal={Clinical & Experimental Allergy}, publisher={Wiley}, author={Böttcher, M. F. and Nordin, E. K. and Sandin, A. and Midtvedt, T. and Björkstén, B.}, year={2000}, month=nov, pages={1591–1596} }

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