DOI: 10.1046/j.1365-2184.36.s.1.6.x. Stem cells in normal breast development and breast cancer

Stem cells in normal breast development and breast cancer

10.1046/j.1365-2184.36.s.1.6.x

Crossref journal-article

Wiley

Cell Proliferation (311)

Abstract

Abstract. The main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis. We have developed a new in vitro culture system that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammary stem‐cell self‐renewal and differentiation. Furthermore, we propose a model in which transformation of stem cells, or early progenitor cells, results in carcinogenesis. A key event in this process is the deregulation of normal self‐renewal in these cells. Transformed mammary stem or progenitor cells undergo aberrant differentiation processes that result in generation of the phenotypic heterogeneity found in human and rodent breast cancers. This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem‐cell model.

Bibliography

Dontu, G., AlâHajj, M., Abdallah, W. M., Clarke, M. F., & Wicha, M. S. (2003). Stem cells in normal breast development and breast cancer. Cell Proliferation, 36(s1), 59â72. Portico.

Authors 5

Gabriela Dontu (first)
Muhammad Al‐Hajj (additional)
Wissam M. Abdallah (additional)
Michael F. Clarke (additional)
Max S. Wicha (additional)

References 55 Referenced 455

10.1073/pnas.0530291100
10.1002/path.1155
10.1002/stem.200011
10.1038/88158
10.1016/0531-5565(71)90053-2
10.1016/S0168-9525(98)01424-3
10.1023/A:1005942923757
10.1101/gad.1061803
10.1146/annurev.neuro.25.030702.130823
10.4049/jimmunol.167.8.4747
10.1016/S0896-6273(01)00209-4
10.1006/dbio.2000.9611
10.1126/science.1065518
10.1101/gad.952602
10.1016/S1534-5807(01)00064-8
10.1126/science.1073823
10.1006/excr.2000.5013
10.1038/sj.onc.1205462
10.1242/dev.125.10.1921
10.1038/sj.onc.1205316
10.2307/3579773
10.1038/35065016
10.1006/dbio.2000.9960
{'key': 'e_1_2_14_25_1', 'first-page': '2817', 'article-title': 'Division of labor among the α6β4 integrin β1 integrins, and an E3 laminin receptor to signal morphogenesis and β‐casein expression in mammary epithelial cells', 'volume': '10', 'author': 'Muschler J', 'year': '1999', 'journal-title': 'Mol. Biol.'} / Mol. Biol. / Division of labor among the α6β4 integrin β1 integrins, and an E3 laminin receptor to signal morphogenesis and β‐casein expression in mammary epithelial cells by Muschler J (1999)
10.1126/science.283.5403.845
10.1186/bcr322
10.1101/gad.14.15.1837 / Gen. Dev. / Wnt signaling and cancer by Polakis P (2000)
10.1126/science.1072530
10.1038/35102167
10.1006/dbio.1996.0090
10.1038/35054579
10.1016/B978-012563455-7/50008-8
10.1016/S0166-2236(99)01416-2
10.1074/jbc.M201975200
10.1523/JNEUROSCI.21-19-07642.2001
10.1242/dev.128.16.3117
10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O
10.1002/(SICI)1097-0215(20000601)86:5<652::AID-IJC8>3.0.CO;2-V
10.1111/j.1432-0436.1998.00201.x
10.1023/A:1010615124301
10.1002/1097-0029(20010115)52:2<171::AID-JEMT1003>3.0.CO;2-T
10.1023/A:1018729308878
10.1074/jbc.M110603200
10.1016/S0014-5793(02)03040-5
10.1016/S1470-2045(02)00820-3
10.1073/pnas.97.26.14720
10.1006/dbio.1998.8863
10.1056/NEJMoa021967
10.1038/415530a
10.1073/pnas.251547698
10.1016/S0166-2236(96)10035-7
10.1006/dbio.2002.0625
10.1126/science.1067431
10.1016/S0959-4388(99)00020-3
10.1038/nm0901-1028

Dates

Type	When
Created	21 years, 10 months ago (Oct. 14, 2003, 8:58 a.m.)
Deposited	1 year, 10 months ago (Sept. 26, 2023, 12:45 p.m.)
Indexed	11 months ago (Sept. 17, 2024, 6:48 a.m.)
Issued	21 years, 10 months ago (Oct. 1, 2003)
Published	21 years, 10 months ago (Oct. 1, 2003)
Published Online	21 years, 10 months ago (Oct. 2, 2003)
Published Print	21 years, 10 months ago (Oct. 1, 2003)

Funders 0

None

BibTeX

@article{Dontu_2003, title={Stem cells in normal breast development and breast cancer}, volume={36}, ISSN={1365-2184}, url={http://dx.doi.org/10.1046/j.1365-2184.36.s.1.6.x}, DOI={10.1046/j.1365-2184.36.s.1.6.x}, number={s1}, journal={Cell Proliferation}, publisher={Wiley}, author={Dontu, Gabriela and Al‐Hajj, Muhammad and Abdallah, Wissam M. and Clarke, Michael F. and Wicha, Max S.}, year={2003}, month=oct, pages={59–72} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        17
      ]
    ],
    "date-time": "2024-09-17T10:48:11Z",
    "timestamp": 1726570091662
  },
  "reference-count": 55,
  "publisher": "Wiley",
  "issue": "s1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            10,
            2
          ]
        ],
        "date-time": "2003-10-02T00:00:00Z",
        "timestamp": 1065052800000
      },
      "content-version": "vor",
      "delay-in-days": 1,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        10
      ]
    ]
  },
  "abstract": "<jats:p><jats:bold>Abstract.\u2002</jats:bold> The main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis. We have developed a new <jats:italic>in\u00a0vitro</jats:italic> culture system that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammary stem\u2010cell self\u2010renewal and differentiation. Furthermore, we propose a model in which transformation of stem cells, or early progenitor cells, results in carcinogenesis. A key event in this process is the deregulation of normal self\u2010renewal in these cells. Transformed mammary stem or progenitor cells undergo aberrant differentiation processes that result in generation of the phenotypic heterogeneity found in human and rodent breast cancers. This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem\u2010cell model.</jats:p>",
  "DOI": "10.1046/j.1365-2184.36.s.1.6.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        10,
        14
      ]
    ],
    "date-time": "2003-10-14T12:58:10Z",
    "timestamp": 1066136290000
  },
  "page": "59-72",
  "source": "Crossref",
  "is-referenced-by-count": 455,
  "title": "Stem cells in normal breast development and breast cancer",
  "prefix": "10.1111",
  "volume": "36",
  "author": [
    {
      "given": "Gabriela",
      "family": "Dontu",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Muhammad",
      "family": "Al\u2010Hajj",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wissam M.",
      "family": "Abdallah",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Michael F.",
      "family": "Clarke",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Max S.",
      "family": "Wicha",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2003,
        10,
        2
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_14_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0530291100"
    },
    {
      "key": "e_1_2_14_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/path.1155"
    },
    {
      "key": "e_1_2_14_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/stem.200011"
    },
    {
      "key": "e_1_2_14_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/88158"
    },
    {
      "key": "e_1_2_14_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0531-5565(71)90053-2"
    },
    {
      "key": "e_1_2_14_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0168-9525(98)01424-3"
    },
    {
      "key": "e_1_2_14_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/A:1005942923757"
    },
    {
      "key": "e_1_2_14_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.1061803"
    },
    {
      "key": "e_1_2_14_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.neuro.25.030702.130823"
    },
    {
      "key": "e_1_2_14_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.4049/jimmunol.167.8.4747"
    },
    {
      "key": "e_1_2_14_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0896-6273(01)00209-4"
    },
    {
      "key": "e_1_2_14_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.2000.9611"
    },
    {
      "key": "e_1_2_14_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1065518"
    },
    {
      "key": "e_1_2_14_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.952602"
    },
    {
      "key": "e_1_2_14_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1534-5807(01)00064-8"
    },
    {
      "key": "e_1_2_14_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1073823"
    },
    {
      "key": "e_1_2_14_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/excr.2000.5013"
    },
    {
      "key": "e_1_2_14_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1205462"
    },
    {
      "key": "e_1_2_14_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/dev.125.10.1921"
    },
    {
      "key": "e_1_2_14_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1205316"
    },
    {
      "key": "e_1_2_14_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.2307/3579773"
    },
    {
      "key": "e_1_2_14_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35065016"
    },
    {
      "key": "e_1_2_14_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.2000.9960"
    },
    {
      "key": "e_1_2_14_25_1",
      "first-page": "2817",
      "article-title": "Division of labor among the \u03b16\u03b24 integrin \u03b21 integrins, and an E3 laminin receptor to signal morphogenesis and \u03b2\u2010casein expression in mammary epithelial cells",
      "volume": "10",
      "author": "Muschler J",
      "year": "1999",
      "journal-title": "Mol. Biol."
    },
    {
      "key": "e_1_2_14_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.283.5403.845"
    },
    {
      "key": "e_1_2_14_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1186/bcr322"
    },
    {
      "key": "e_1_2_14_28_1",
      "doi-asserted-by": "crossref",
      "first-page": "1837",
      "DOI": "10.1101/gad.14.15.1837",
      "article-title": "Wnt signaling and cancer",
      "volume": "14",
      "author": "Polakis P",
      "year": "2000",
      "journal-title": "Gen. Dev."
    },
    {
      "key": "e_1_2_14_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1072530"
    },
    {
      "key": "e_1_2_14_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35102167"
    },
    {
      "key": "e_1_2_14_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.1996.0090"
    },
    {
      "key": "e_1_2_14_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35054579"
    },
    {
      "key": "e_1_2_14_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/B978-012563455-7/50008-8"
    },
    {
      "key": "e_1_2_14_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0166-2236(99)01416-2"
    },
    {
      "key": "e_1_2_14_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M201975200"
    },
    {
      "key": "e_1_2_14_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.21-19-07642.2001"
    },
    {
      "key": "e_1_2_14_37_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/dev.128.16.3117"
    },
    {
      "key": "e_1_2_14_38_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O"
    },
    {
      "key": "e_1_2_14_39_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-0215(20000601)86:5<652::AID-IJC8>3.0.CO;2-V"
    },
    {
      "key": "e_1_2_14_40_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-0436.1998.00201.x"
    },
    {
      "key": "e_1_2_14_41_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/A:1010615124301"
    },
    {
      "key": "e_1_2_14_42_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/1097-0029(20010115)52:2<171::AID-JEMT1003>3.0.CO;2-T"
    },
    {
      "key": "e_1_2_14_43_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/A:1018729308878"
    },
    {
      "key": "e_1_2_14_44_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M110603200"
    },
    {
      "key": "e_1_2_14_45_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(02)03040-5"
    },
    {
      "key": "e_1_2_14_46_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1470-2045(02)00820-3"
    },
    {
      "key": "e_1_2_14_47_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.97.26.14720"
    },
    {
      "key": "e_1_2_14_48_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.1998.8863"
    },
    {
      "key": "e_1_2_14_49_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1056/NEJMoa021967"
    },
    {
      "key": "e_1_2_14_50_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/415530a"
    },
    {
      "key": "e_1_2_14_51_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.251547698"
    },
    {
      "key": "e_1_2_14_52_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0166-2236(96)10035-7"
    },
    {
      "key": "e_1_2_14_53_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/dbio.2002.0625"
    },
    {
      "key": "e_1_2_14_54_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1067431"
    },
    {
      "key": "e_1_2_14_55_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0959-4388(99)00020-3"
    },
    {
      "key": "e_1_2_14_56_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nm0901-1028"
    }
  ],
  "container-title": "Cell Proliferation",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2184.36.s.1.6.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2184.36.s.1.6.x",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2184.36.s.1.6.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        26
      ]
    ],
    "date-time": "2023-09-26T16:45:38Z",
    "timestamp": 1695746738000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2184.36.s.1.6.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        10
      ]
    ]
  },
  "references-count": 55,
  "journal-issue": {
    "issue": "s1",
    "published-print": {
      "date-parts": [
        [
          2003,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1046/j.1365-2184.36.s.1.6.x"
  ],
  "URL": "http://dx.doi.org/10.1046/j.1365-2184.36.s.1.6.x",
  "relation": {},
  "ISSN": [
    "0960-7722",
    "1365-2184"
  ],
  "subject": [],
  "container-title-short": "Cell Proliferation",
  "published": {
    "date-parts": [
      [
        2003,
        10
      ]
    ]
  }
}