DOI: 10.1046/j.0953-816x.2001.01740.x. Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons

Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons

10.1046/j.0953-816x.2001.01740.x

Crossref journal-article

Wiley

European Journal of Neuroscience (311)

Abstract

AbstractLong‐term synaptic plasticity is thought to underlie synaptic reorganization phenomena that occur during neocortical development. Recently, it has been proposed, that the functional induction of AMPA receptors at silent glutamatergic synapses is of major importance in activity‐dependent, developmental plasticity. To investigate the mechanisms involved in the developmental regulation of silent synapses, we analysed the functional maturation of the thalamocortical projection in culture. A large proportion of the thalamocortical synapses were functionally silent at an early stage in vitro. During further differentiation, the incidence of silent synapses decreased drastically, indicating a conversion of silent into functional synapses. Chronic blockade of spontaneous network activity by addition of tetrodotoxin to the culture medium strongly impaired this developmental maturation. Moreover, the developmental decline in the proportion of silent synapses was dramatically accelerated by chronic addition of the neurotrophic factor, insulin. This effect of insulin was partly dependent on spontaneous activity. Thus, insulin appears to be involved in the modulation of long‐term developmental plasticity at immature glutamatergic synapses.

Bibliography

Plitzko, D., Rumpel, S., & Gottmann, K. (2001). Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons. European Journal of Neuroscience, 14(8), 1412â1415. Portico.

Authors 3

Daniela Plitzko (first)
Simon Rumpel (additional)
Kurt Gottmann (additional)

References 25 Referenced 34

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Dates

Type	When
Created	22 years, 5 months ago (March 6, 2003, 9:42 a.m.)
Deposited	1 year, 11 months ago (Oct. 3, 2023, 7:55 a.m.)
Indexed	1 year, 5 months ago (April 1, 2024, 2:28 a.m.)
Issued	23 years, 11 months ago (Oct. 1, 2001)
Published	23 years, 11 months ago (Oct. 1, 2001)
Published Online	23 years, 8 months ago (Dec. 20, 2001)
Published Print	23 years, 11 months ago (Oct. 1, 2001)

Funders 0

None

BibTeX

@article{Plitzko_2001, title={Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons}, volume={14}, ISSN={1460-9568}, url={http://dx.doi.org/10.1046/j.0953-816x.2001.01740.x}, DOI={10.1046/j.0953-816x.2001.01740.x}, number={8}, journal={European Journal of Neuroscience}, publisher={Wiley}, author={Plitzko, Daniela and Rumpel, Simon and Gottmann, Kurt}, year={2001}, month=oct, pages={1412–1415} }

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