DOI: 10.1042/cs0680113. Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

10.1042/cs0680113

Crossref journal-article

Portland Press Ltd.

Clinical Science (288)

Abstract

The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor system. However, there are theoretical and experimental grounds for studying therapeutic applications in cerebral ischaemia and in chronic degenerative disorders. This review summarizes the experimental background, and proposes some key future studies.

Bibliography

Meldrum, B. (1985). Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters. Clinical Science, 68(2), 113â122.

Authors 1

Brian Meldrum (first)

References 0 Referenced 472

None

Dates

Type	When
Created	10 years ago (Aug. 7, 2015, 6:57 a.m.)
Deposited	3 years, 8 months ago (Dec. 2, 2021, 3:38 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 12, 2024, 9:30 p.m.)
Issued	40 years, 6 months ago (Feb. 1, 1985)
Published	40 years, 6 months ago (Feb. 1, 1985)
Published Print	40 years, 6 months ago (Feb. 1, 1985)

Funders 0

None

BibTeX

@article{Meldrum_1985, title={Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters}, volume={68}, ISSN={1470-8736}, url={http://dx.doi.org/10.1042/cs0680113}, DOI={10.1042/cs0680113}, number={2}, journal={Clinical Science}, publisher={Portland Press Ltd.}, author={Meldrum, Brian}, year={1985}, month=feb, pages={113–122} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        13
      ]
    ],
    "date-time": "2024-09-13T01:30:49Z",
    "timestamp": 1726191049107
  },
  "reference-count": 0,
  "publisher": "Portland Press Ltd.",
  "issue": "2",
  "content-domain": {
    "domain": [
      "portlandpress.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1985,
        2,
        1
      ]
    ]
  },
  "abstract": "<jats:p>The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor system. However, there are theoretical and experimental grounds for studying therapeutic applications in cerebral ischaemia and in chronic degenerative disorders. This review summarizes the experimental background, and proposes some key future studies.</jats:p>",
  "DOI": "10.1042/cs0680113",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2015,
        8,
        7
      ]
    ],
    "date-time": "2015-08-07T10:57:35Z",
    "timestamp": 1438945055000
  },
  "page": "113-122",
  "update-policy": "http://dx.doi.org/10.1042/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 472,
  "title": "Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters",
  "prefix": "10.1042",
  "volume": "68",
  "author": [
    {
      "given": "Brian",
      "family": "Meldrum",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Neurology, Institute of Psychiatry, London"
        }
      ]
    }
  ],
  "member": "288",
  "container-title": "Clinical Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://portlandpress.com/clinsci/article-pdf/68/2/113/451067/cs0680113.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://portlandpress.com/clinsci/article-pdf/68/2/113/451067/cs0680113.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        2
      ]
    ],
    "date-time": "2021-12-02T20:38:50Z",
    "timestamp": 1638477530000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://portlandpress.com/clinsci/article/68/2/113/73657/Possible-Therapeutic-Applications-of-Antagonists"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1985,
        2,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1985,
          2,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1042/cs0680113",
  "relation": {},
  "ISSN": [
    "0143-5221",
    "1470-8736"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1985,
        2,
        1
      ]
    ]
  }
}