DOI: 10.1042/bj3410665. APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

10.1042/bj3410665

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

APS (adapter protein with a PH and SH2 domain) is the newest member of a family of tyrosine kinase adapter proteins including SH2-B and Lnk. We previously identified SH2-B as an insulin-receptor-binding protein and substrate [Kotani, Wilden and Pillay (1998) Biochem J. 335, 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158 and 1162 are required for this interaction.

Bibliography

AHMED, Z., SMITH, B. J., KOTANI, K., WILDEN, P., & PILLAY, T. S. (1999). APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase. Biochemical Journal, 341(3), 665â668.

Authors 5

Zamal AHMED (first)
Beverley J. SMITH (additional)
Kei KOTANI (additional)
Peter WILDEN (additional)
Tahir S. PILLAY (additional)

References 0 Referenced 45

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 6:06 p.m.)
Deposited	3 years, 9 months ago (Nov. 23, 2021, 7:54 p.m.)
Indexed	1 year, 5 months ago (March 20, 2024, 10:02 p.m.)
Issued	26 years, 1 month ago (July 26, 1999)
Published	26 years, 1 month ago (July 26, 1999)
Published Online	26 years, 1 month ago (July 26, 1999)
Published Print	26 years ago (Aug. 1, 1999)

Funders 0

None

BibTeX

@article{AHMED_1999, title={APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase}, volume={341}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj3410665}, DOI={10.1042/bj3410665}, number={3}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={AHMED, Zamal and SMITH, Beverley J. and KOTANI, Kei and WILDEN, Peter and PILLAY, Tahir S.}, year={1999}, month=jul, pages={665–668} }

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