DOI: 10.1042/bj3240201. Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta

Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta

10.1042/bj3240201

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

The presence of the calcium-independent cytokine-inducible nitric oxide synthase (iNOS) has been investigated in rat placenta from day 19 of gestation till delivery. iNOS has been detected at the mRNA, enzyme activity and protein levels in complete placenta. Immunocytochemical detection of iNOS was heterogeneously distributed in control placenta. Intraperitoneal injection of pregnant rats at 21 days of gestation with lipopolysaccharide (LPS) increased the iNOS immunoreactivity in the decidua basalis of the placenta, and, when the mRNA levels and enzyme activity were measured in total tissue, a moderate increase (approx. 160%) was observed. A constitutive nuclear factor κB activity was observed in placenta from both control and LPS-treated animals. These results indicate constitutive expression of iNOS in rat placenta.

Bibliography

CASADO, M., DÃAZ-GUERRA, M. J. M., RODRIGO, J., FERNÃNDEZ, A. P., BOSCÃ, L., & MARTÃN-SANZ, P. (1997). Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta. Biochemical Journal, 324(1), 201â207.

Authors 6

Marta CASADO (first)
María J. M. DÍAZ-GUERRA (additional)
José RODRIGO (additional)
Ana P. FERNÁNDEZ (additional)
Lisardo BOSCÁ (additional)
Paloma MARTÍN-SANZ (additional)

References 0 Referenced 19

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:54 p.m.)
Deposited	3 years, 9 months ago (Nov. 23, 2021, 7:23 p.m.)
Indexed	1 year, 1 month ago (July 1, 2024, 9:16 a.m.)
Issued	28 years, 3 months ago (May 15, 1997)
Published	28 years, 3 months ago (May 15, 1997)
Published Print	28 years, 3 months ago (May 15, 1997)

Funders 0

None

BibTeX

@article{CASADO_1997, title={Expression of the calcium-independent cytokine-inducible (iNOS) isoform of nitric oxide synthase in rat placenta}, volume={324}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj3240201}, DOI={10.1042/bj3240201}, number={1}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={CASADO, Marta and DÍAZ-GUERRA, María J. M. and RODRIGO, José and FERNÁNDEZ, Ana P. and BOSCÁ, Lisardo and MARTÍN-SANZ, Paloma}, year={1997}, month=may, pages={201–207} }

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