DOI: 10.1042/bj3190009. Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression

Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression

10.1042/bj3190009

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

Polypeptide growth factors promote cell-cycle progression in part by the transcriptional activation of a diverse group of specific genes. We have used an mRNA differential-display approach to identify several fibroblast growth factor (FGF)-1 (acidic FGF)-inducible genes in NIH 3T3 cells. Here we report that one of these genes, called FGF-regulated (FR)-3, is predicted to encode G/T mismatch-binding protein (GTBP), a component of the mammalian DNA mismatch correction system. The murine GTBP gene is transiently expressed after FGF-1 or calf serum treatment, with maximal mRNA levels detected at 12 and 18 h post-stimulation. FGF-1-stimulated NIH 3T3 cells also express an increased amount of GTBP as determined by immunoblot analysis. These results indicate that elevated levels of GTBP may be required during the DNA synthesis phase of the cell cycle for efficient G/T mismatch recognition and repair.

Bibliography

DONOHUE, P. J., FENG, S.-L. Y., ALBERTS, G. F., GUO, Y., PEIFLEY, K. A., HSU, D. K. W., & WINKLES, J. A. (1996). Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression. Biochemical Journal, 319(1), 9â12.

Authors 7

Patrick J. DONOHUE (first)
Sheau-Line Y. FENG (additional)
Gregory F ALBERTS (additional)
Yan GUO (additional)
Kimberly A PEIFLEY (additional)
Debbie K. W. HSU (additional)
Jeffrey A. WINKLES (additional)

References 0 Referenced 6

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:51 p.m.)
Deposited	3 years, 9 months ago (Nov. 23, 2021, 8:03 p.m.)
Indexed	1 year, 10 months ago (Oct. 16, 2023, 9:08 p.m.)
Issued	28 years, 10 months ago (Oct. 1, 1996)
Published	28 years, 10 months ago (Oct. 1, 1996)
Published Print	28 years, 10 months ago (Oct. 1, 1996)

Funders 0

None

BibTeX

@article{DONOHUE_1996, title={Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression}, volume={319}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj3190009}, DOI={10.1042/bj3190009}, number={1}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={DONOHUE, Patrick J. and FENG, Sheau-Line Y. and ALBERTS, Gregory F and GUO, Yan and PEIFLEY, Kimberly A and HSU, Debbie K. W. and WINKLES, Jeffrey A.}, year={1996}, month=oct, pages={9–12} }

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