DOI: 10.1042/bj3120661. Phospholipase C <i>δ</i>1 requires a pleckstrin homology domain for interaction with the plasma membrane

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

10.1042/bj3120661

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

The structural requirements of phospholipase C delta 1 for interaction with the plasma membrane were analysed by immunofluorescence after microinjection into living cells. Microinjection of deletion mutants revealed that the region required for membrane attachment and binding of inositol 1,4,5-trisphosphate in vitro corresponded to the pleckstrin homology domain, a structural module described in more than 90 proteins.

Bibliography

Paterson, H. F., Savopoulos, J. W., Perisic, O., Cheung, R., Ellis, M. V., Williams, R. L., & Katan, M. (1995). Phospholipase C Î´1 requires a pleckstrin homology domain for interaction with the plasma membrane. Biochemical Journal, 312(3), 661â666.

Authors 7

H F Paterson (first)
J W Savopoulos (additional)
O Perisic (additional)
R Cheung (additional)
M V Ellis (additional)
R L Williams (additional)
M Katan (additional)

References 0 Referenced 93

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:46 p.m.)
Deposited	3 years, 9 months ago (Nov. 23, 2021, 8:06 p.m.)
Indexed	1 year, 7 months ago (Jan. 13, 2024, 4:18 a.m.)
Issued	29 years, 8 months ago (Dec. 15, 1995)
Published	29 years, 8 months ago (Dec. 15, 1995)
Published Print	29 years, 8 months ago (Dec. 15, 1995)

Funders 0

None

BibTeX

@article{Paterson_1995, title={Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane}, volume={312}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj3120661}, DOI={10.1042/bj3120661}, number={3}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Paterson, H F and Savopoulos, J W and Perisic, O and Cheung, R and Ellis, M V and Williams, R L and Katan, M}, year={1995}, month=dec, pages={661–666} }

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