DOI: 10.1042/bj2880553. Expression of a cardiac Ca2+-release channel isoform in mammalian brain

Expression of a cardiac Ca2+-release channel isoform in mammalian brain

10.1042/bj2880553

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

Mammalian brain possesses ryanodine-sensitive Ca2+ channels, which in muscle cells mediate rapid Ca2+ release from intracellular stores during excitation-contraction coupling. Analysis of bovine brain ryanodine receptor (RyR) channels suggests specific expression of the cardiac-muscle RyR isoform in mammalian brain. Localization using cardiac-muscle RyR-specific antibodies and antisense RNA revealed that brain RyRs were present in dendrites, cell bodies and terminals of rat forebrain, and highly enriched in the hippocampus. Activity of skeletal-muscle RyR channels is coupled to sarcolemmal voltage sensors, in contrast with cardiac-muscle RyR channels, which are known to be Ca(2+)-induced Ca(2+)-release channels. Thus Ca(2+)-induced Ca2+ release from intracellular stores mediated by brain RyR channels may be a major Ca(2+)-signalling pathway in specific regions of mammalian brain, and hence may play a fundamental role in neuronal Ca2+ homoeostasis.

Bibliography

Lai, F. A., Dent, M., Wickenden, C., Xu, L., Kumari, G., Misra, M., Lee, H. B., Sar, M., & Meissner, G. (1992). Expression of a cardiac Ca2+-release channel isoform in mammalian brain. Biochemical Journal, 288(2), 553â564.

Authors 9

F A Lai (first)
M Dent (additional)
C Wickenden (additional)
L Xu (additional)
G Kumari (additional)
M Misra (additional)
H B Lee (additional)
M Sar (additional)
G Meissner (additional)

References 0 Referenced 75

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:29 p.m.)
Deposited	3 years, 9 months ago (Nov. 23, 2021, 5:13 p.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 3:55 p.m.)
Issued	32 years, 8 months ago (Dec. 1, 1992)
Published	32 years, 8 months ago (Dec. 1, 1992)
Published Print	32 years, 8 months ago (Dec. 1, 1992)

Funders 0

None

BibTeX

@article{Lai_1992, title={Expression of a cardiac Ca2+-release channel isoform in mammalian brain}, volume={288}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj2880553}, DOI={10.1042/bj2880553}, number={2}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Lai, F A and Dent, M and Wickenden, C and Xu, L and Kumari, G and Misra, M and Lee, H B and Sar, M and Meissner, G}, year={1992}, month=dec, pages={553–564} }

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