DOI: 10.1042/bj2720743. Involvement of an NAD(P)H oxidase as a <i>p</i>O2 sensor protein in the rat carotid body

Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body

10.1042/bj2720743

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

The rat carotid body tissue reveals a photometrically measurable haem signal with absorbance maxima at 560 nm, 518 nm and 425 nm, suggesting the presence of a b-type cytochrome; this was confirmed by pyridine haemochrome and CO spectra. The quantity of cytochrome b was estimated to be 310 pmol.mg of protein-1. This haem is capable of H2O2 formation, which can be inhibited by 10 microM-diphenyliodonium (DPI). The hypoxia-induced increase in nervous chemoreceptor discharge and the reduction of FAD and NAD(P)+ were also inhibited by DPI (10 microM). These results suggest that an oxidase such as the NAD(P)H oxidase of neutrophils may act as a pO2 sensor protein in the rat carotid body, probably inducing the pO2 chemoreceptor process by H2O2 formation.

Bibliography

Cross, A. R., Henderson, L., Jones, O. T. G., Delpiano, M. A., Hentschel, J., & Acker, H. (1990). Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body. Biochemical Journal, 272(3), 743â747.

Authors 6

A R Cross (first)
L Henderson (additional)
O T G Jones (additional)
M A Delpiano (additional)
J Hentschel (additional)
H Acker (additional)

References 0 Referenced 171

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:18 p.m.)
Deposited	3 years, 9 months ago (Nov. 25, 2021, 1:41 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 9:41 a.m.)
Issued	34 years, 8 months ago (Dec. 15, 1990)
Published	34 years, 8 months ago (Dec. 15, 1990)
Published Print	34 years, 8 months ago (Dec. 15, 1990)

Funders 0

None

BibTeX

@article{Cross_1990, title={Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body}, volume={272}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj2720743}, DOI={10.1042/bj2720743}, number={3}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Cross, A R and Henderson, L and Jones, O T G and Delpiano, M A and Hentschel, J and Acker, H}, year={1990}, month=dec, pages={743–747} }

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