DOI: 10.1042/bj2580403. Characteristics and adaptive regulation of glycine transport in cultured glial cells

Characteristics and adaptive regulation of glycine transport in cultured glial cells

10.1042/bj2580403

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

The transport of glycine in C6 glioma cells takes place mainly in a heterogeneous Na+-dependent manner which can be resolved into different components. A Na+- and Cl(-)-dependent component with high affinity for glycine is pH-sensitive and inhibited by sarcosine, all these characteristics corresponding to System Gly. The low-affinity component of the transport of glycine can be discriminated as two components, namely System A and System ASC. The main proportion of glycine transport through the low-affinity system is carried out by the ASC System, which appears to be constitutively expressed by the cells. The adaptive response of the low-affinity Na+-dependent transport of glycine to amino acid deprivation was identified with System A on the basis of its ion-dependency, pH-sensitivity and by inhibition analysis. The possible physiological role of the high- and low-affinity components of the transport system for glycine in glial cells is discussed.

Bibliography

Zafra, F., & GimÃ©nez, C. (1989). Characteristics and adaptive regulation of glycine transport in cultured glial cells. Biochemical Journal, 258(2), 403â408.

Authors 2

F Zafra (first)
C Giménez (additional)

References 0 Referenced 24

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:13 p.m.)
Deposited	3 years, 9 months ago (Nov. 25, 2021, 1:03 p.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 10:32 a.m.)
Issued	36 years, 5 months ago (March 1, 1989)
Published	36 years, 5 months ago (March 1, 1989)
Published Print	36 years, 5 months ago (March 1, 1989)

Funders 0

None

BibTeX

@article{Zafra_1989, title={Characteristics and adaptive regulation of glycine transport in cultured glial cells}, volume={258}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj2580403}, DOI={10.1042/bj2580403}, number={2}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Zafra, F and Giménez, C}, year={1989}, month=mar, pages={403–408} }

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