DOI: 10.1042/bj2520309. Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein

Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein

10.1042/bj2520309

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

Human skin fibroblasts were exposed to various concentrations (from 0.01 to 5.0 units/ml) of human recombinant interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta). Both IL-1 alpha and IL-1 beta were found to increase dermatan-sulphate-proteoglycan (DSPG) core-protein mRNA levels. Maximal increase (3.0-fold) was seen at 48 h after addition of 1 unit of IL-1 beta/ml. In spite of the elevated DSPG-core-protein mRNA only a slight increase (from 10 to 18%) could be seen in the production of DSPG to cell-culture medium. No changes in the molecular mass of DSPG could be detected.

Bibliography

Heino, J., KÃ¤hÃ¤ri, V. M., Mauviel, A., & Krusius, T. (1988). Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein. Biochemical Journal, 252(1), 309â312.

Authors 4

J Heino (first)
V M Kähäri (additional)
A Mauviel (additional)
T Krusius (additional)

References 0 Referenced 32

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 5:11 p.m.)
Deposited	3 years, 9 months ago (Nov. 25, 2021, 2:32 p.m.)
Indexed	3 months, 3 weeks ago (May 7, 2025, 5:31 a.m.)
Issued	37 years, 3 months ago (May 15, 1988)
Published	37 years, 3 months ago (May 15, 1988)
Published Print	37 years, 3 months ago (May 15, 1988)

Funders 0

None

BibTeX

@article{Heino_1988, title={Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein}, volume={252}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj2520309}, DOI={10.1042/bj2520309}, number={1}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Heino, J and Kähäri, V M and Mauviel, A and Krusius, T}, year={1988}, month=may, pages={309–312} }

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