DOI: 10.1042/bj2310755. Effects <i>in vivo</i> of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (<i>gsd/gsd</i>) rat

Effects in vivo of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (gsd/gsd) rat

10.1042/bj2310755

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

Intraperitoneal injection of 3-mercaptopicolinate into 24 h-food-deprived 27-week-old female control (GSD/GSD) rats lowered the concentration of circulating glucose by 66%, but glycerol and lactate concentrations were increased up to 3- and 4-fold respectively. In phosphorylase b kinase-deficient (gsd/gsd) rats the corresponding changes for blood glucose, lactate and glycerol were half those observed in the controls. Although the concentration of liver glycogen (approx. 12%, w/w) in the gsd/gsd rats was not altered during food deprivation, total hepatic glycogen was decreased by 17%. It is suggested that the gradual breakdown of the extensive hepatic glycogen stores during starvation assists in the maintenance of normoglycaemia in the gsd/gsd rat.

Bibliography

Clark, D. G., Brinkman, M., Neville, S. D., & Haynes, W. D. (1985). Effects in vivo of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (gsd/gsd) rat. Biochemical Journal, 231(3), 755â759.

Authors 4

D G Clark (first)
M Brinkman (additional)
S D Neville (additional)
W D Haynes (additional)

References 0 Referenced 3

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 4:50 p.m.)
Deposited	3 years, 9 months ago (Nov. 25, 2021, 7:06 a.m.)
Indexed	3 years, 5 months ago (March 31, 2022, 6:42 a.m.)
Issued	39 years, 10 months ago (Nov. 1, 1985)
Published	39 years, 10 months ago (Nov. 1, 1985)
Published Print	39 years, 10 months ago (Nov. 1, 1985)

Funders 0

None

BibTeX

@article{Clark_1985, title={Effects in vivo of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (gsd/gsd) rat}, volume={231}, ISSN={1470-8728}, url={http://dx.doi.org/10.1042/bj2310755}, DOI={10.1042/bj2310755}, number={3}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Clark, D G and Brinkman, M and Neville, S D and Haynes, W D}, year={1985}, month=nov, pages={755–759} }

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