DOI: 10.1042/bj1810639. Native cross-links in collagen fibrils induce resistance to human synovial collagenase

Native cross-links in collagen fibrils induce resistance to human synovial collagenase

10.1042/bj1810639

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

A model system consisting of highly purified lysyl oxidase and reconstituted lathyritic chick bone collagen fibrils was used to study the effect of collagen cross-linking on collagen degradation by mammalian collagenase. The results indicate that synthesis of approx. 0.1 Schiff-base cross-link per collagen molecule results in a 2–3-fold resistance to human synovial collagenase when compared with un-cross-linked controls or samples incubated in the presence of beta-aminopropionitrile to inhibit cross-linking. These results confirm previous studies utilizing artificially cross-linked collagens, or collagens isolated as insoluble material after cross-linking in vivo, and suggest that increased resistance to collagenase may be one of the earliest effects of cross-linking in vivo. The extent of intermolecular cross-linking among collagen fibrils may provide a mechanism for regulating the rate of collagen catabolism relative to synthesis in normal and pathological conditions.

Bibliography

Vater, C. A., Harris, E. D., & Siegel, R. C. (1979). Native cross-links in collagen fibrils induce resistance to human synovial collagenase. Biochemical Journal, 181(3), 639â645.

Authors 3

C A Vater (first)
E D Harris (additional)
R C Siegel (additional)

References 0 Referenced 169

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 4:16 p.m.)
Deposited	3 years, 9 months ago (Nov. 26, 2021, 8:09 a.m.)
Indexed	1 month, 2 weeks ago (July 23, 2025, 8:33 a.m.)
Issued	46 years ago (Sept. 1, 1979)
Published	46 years ago (Sept. 1, 1979)
Published Print	46 years ago (Sept. 1, 1979)

Funders 0

None

BibTeX

@article{Vater_1979, title={Native cross-links in collagen fibrils induce resistance to human synovial collagenase}, volume={181}, ISSN={0264-6021}, url={http://dx.doi.org/10.1042/bj1810639}, DOI={10.1042/bj1810639}, number={3}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Vater, C A and Harris, E D and Siegel, R C}, year={1979}, month=sep, pages={639–645} }

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