DOI: 10.1042/bj1500077. The role of intermediates in mitochondrial fatty acid oxidation

The role of intermediates in mitochondrial fatty acid oxidation

10.1042/bj1500077

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

1. Rat liver mitochondria oxidizing [16-14C]palmitoylcarnitine accumulate saturated long-chain thiester intermediates which may be detected by radio-g.1.c.2. Time-courses of intermediate accumulation display no product-precursor relationships and the end product, measured as [14C]citrate, is produced without a detectable initial lag. 3. A short pulse of [16-14C]palmitoylcarnitine followed by unlabelled palmitoylcarnitine showed that the observed intermediates(at least in the greater part)were not the direct precursors of [14C]citrate. 4. The quantity of saturated intermediates depended on the total accumulated flux of acyl units through the pathway provided that some mitochondrial CoA and unused substrate remained. 5. In the presence of rotenone and carnitine, 2-unsaturated, 3-unsaturated and 3-hydroxy intermediates were formed as well as saturated intermediates…

Bibliography

Stanley, K. K., & Tubbs, P. K. (1975). The role of intermediates in mitochondrial fatty acid oxidation. Biochemical Journal, 150(1), 77â88.

Authors 2

K K Stanley (first)
P K Tubbs (additional)

References 0 Referenced 79

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 11:59 a.m.)
Deposited	3 years, 9 months ago (Nov. 26, 2021, 6:45 a.m.)
Indexed	1 day, 11 hours ago (Sept. 4, 2025, 10:23 a.m.)
Issued	50 years, 2 months ago (July 1, 1975)
Published	50 years, 2 months ago (July 1, 1975)
Published Print	50 years, 2 months ago (July 1, 1975)

Funders 0

None

BibTeX

@article{Stanley_1975, title={The role of intermediates in mitochondrial fatty acid oxidation}, volume={150}, ISSN={0264-6021}, url={http://dx.doi.org/10.1042/bj1500077}, DOI={10.1042/bj1500077}, number={1}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Stanley, K K and Tubbs, P K}, year={1975}, month=jul, pages={77–88} }

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